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    Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [ Mus musculus (house mouse) ]

    Gene ID: 56692, updated on 23-Jun-2021

    Summary

    Official Symbol
    Lamtor3provided by MGI
    Official Full Name
    late endosomal/lysosomal adaptor, MAPK and MTOR activator 3provided by MGI
    Primary source
    MGI:MGI:1929467
    See related
    Ensembl:ENSMUSG00000091512
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mp; Map; Mp1; Map2k; Mapbp; Mapksp1; AW556229; Map2k1ip1
    Expression
    Ubiquitous expression in bladder adult (RPKM 27.6), placenta adult (RPKM 23.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Lamtor3 in Genome Data Viewer
    Location:
    3; 3 G3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (137624316..137634523)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (137918555..137928762)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (137581519..137591726)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B14 Neighboring gene predicted gene, 40155 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene dual adaptor for phosphotyrosine and 3-phosphoinositides 1 Neighboring gene predicted gene, 19708 Neighboring gene RIKEN cDNA 1110002E22 gene Neighboring gene predicted gene 5105

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC103121

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Ragulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Ragulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ragulator complex protein LAMTOR3
    Names
    MAPK scaffold protein 1
    MEK binding partner 1
    late endosomal/lysosomal adaptor and MAPK and MTOR activator 3
    mitogen activated protein, binding protein
    mitogen-activated protein kinase kinase 1-interacting protein 1
    mitogen-activated protein kinase scaffold protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019920.2NP_064304.1  ragulator complex protein LAMTOR3

      See identical proteins and their annotated locations for NP_064304.1

      Status: PROVISIONAL

      Source sequence(s)
      AC146607
      Consensus CDS
      CCDS51078.1
      UniProtKB/Swiss-Prot
      O88653
      UniProtKB/TrEMBL
      Q542I7
      Related
      ENSMUSP00000130811.2, ENSMUST00000168345.6
      Conserved Domains (1) summary
      pfam08923
      Location:3121
      MAPKK1_Int; Mitogen-activated protein kinase kinase 1 interacting

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      137624316..137634523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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