U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    POLE4 DNA polymerase epsilon 4, accessory subunit [ Homo sapiens (human) ]

    Gene ID: 56655, updated on 5-Mar-2024

    Summary

    Official Symbol
    POLE4provided by HGNC
    Official Full Name
    DNA polymerase epsilon 4, accessory subunitprovided by HGNC
    Primary source
    HGNC:HGNC:18755
    See related
    Ensembl:ENSG00000115350 MIM:607269; AllianceGenome:HGNC:18755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p12; YHHQ1
    Summary
    POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
    Expression
    Ubiquitous expression in fat (RPKM 27.9), bone marrow (RPKM 20.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See POLE4 in Genome Data Viewer
    Location:
    2p12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (74958643..74970128)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (74967499..74978982)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (75185770..75197255)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:75061972-75062848 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:75064008-75064523 Neighboring gene Sharpr-MPRA regulatory region 11570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16083 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:75082772-75083312 Neighboring gene hexokinase 2 Neighboring gene uncharacterized LOC105374809 Neighboring gene long intergenic non-protein coding RNA 1291 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:75185356-75185856 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:75185857-75186357 Neighboring gene NANOG hESC enhancer GRCh37_chr2:75211079-75211580 Neighboring gene uncharacterized LOC124907850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11679 Neighboring gene tachykinin receptor 1 Neighboring gene microRNA 5000

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with polymerase (DNA directed), epsilon 4 (POLE4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-directed DNA polymerase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA-templated DNA replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of ATAC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of epsilon DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of epsilon DNA polymerase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of epsilon DNA polymerase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    DNA polymerase epsilon subunit 4
    Names
    DNA polymerase II subunit 4
    DNA polymerase epsilon subunit p12
    polymerase (DNA) epsilon 4, accessory subunit
    polymerase (DNA-directed), epsilon 4, accessory subunit
    NP_063949.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019896.4NP_063949.2  DNA polymerase epsilon subunit 4

      See identical proteins and their annotated locations for NP_063949.2

      Status: VALIDATED

      Source sequence(s)
      AC007400, BC031331, BU594966
      Consensus CDS
      CCDS1957.1
      UniProtKB/Swiss-Prot
      Q53TR2, Q9NR33
      Related
      ENSP00000420176.1, ENST00000483063.2
      Conserved Domains (1) summary
      COG5208
      Location:37112
      HAP5; CCAAT-binding factor, subunit C [Transcription]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      74958643..74970128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      74967499..74978982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)