Format

Send to:

Choose Destination
    • Showing Current items.

    Poll polymerase (DNA directed), lambda [ Mus musculus (house mouse) ]

    Gene ID: 56626, updated on 8-Jul-2021

    Summary

    Official Symbol
    Pollprovided by MGI
    Official Full Name
    polymerase (DNA directed), lambdaprovided by MGI
    Primary source
    MGI:MGI:1889000
    See related
    Ensembl:ENSMUSG00000025218
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AV007317; 1110003P06Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 24.9), ovary adult (RPKM 5.9) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Poll in Genome Data Viewer
    Location:
    19; 19 C3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (45540714..45549025, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (45552275..45560564, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (45626765..45635033, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene beta-transducin repeat containing protein Neighboring gene ribosomal protein L6 pseudogene Neighboring gene predicted gene, 41856 Neighboring gene predicted gene, 19639 Neighboring gene deleted in primary ciliary dyskinesia Neighboring gene AmnSINE1 enhancer AS071 Neighboring gene F-box and WD-40 domain protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-deoxyribose-5-phosphate lyase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA-directed DNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-directed DNA polymerase activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables DNA-directed DNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within base-excision repair, gap-filling ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    involved_in base-excision repair, gap-filling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair via nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleotide-excision repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA polymerase lambda
    Names
    pol Lambda
    NP_001317435.1
    NP_001317436.1
    NP_064416.1
    XP_036017537.1
    XP_036017538.1
    XP_036017539.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330506.1NP_001317435.1  DNA polymerase lambda isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC126454, AK003392, BE949923, BG080424, BY270661
      Consensus CDS
      CCDS29861.1
      UniProtKB/Swiss-Prot
      Q9QXE2
    2. NM_001330507.1NP_001317436.1  DNA polymerase lambda isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK003392, AK133087, BE949923, BG080424, BY270661, BY315476
      UniProtKB/Swiss-Prot
      Q9QXE2
    3. NM_020032.3NP_064416.1  DNA polymerase lambda isoform 1

      See identical proteins and their annotated locations for NP_064416.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK003392, BE949923, BG080424, BY270661, BY315476
      Consensus CDS
      CCDS29861.1
      UniProtKB/Swiss-Prot
      Q9QXE2
      Related
      ENSMUSP00000026239.7, ENSMUST00000026239.7
      Conserved Domains (3) summary
      cd00141
      Location:253571
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
      smart00483
      Location:249572
      POLXc; DNA polymerase X family
      cd00027
      Location:56119
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      45540714..45549025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161644.1XP_036017537.1  DNA polymerase lambda isoform X1

      Conserved Domains (3) summary
      cd00141
      Location:253580
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
      PHA03247
      Location:134231
      PHA03247; large tegument protein UL36; Provisional
      cd17715
      Location:40123
      BRCT_polymerase_lambda; BRCT domain of DNA polymerase lambda and similar proteins
    2. XM_036161646.1XP_036017539.1  DNA polymerase lambda isoform X1

      Conserved Domains (3) summary
      cd00141
      Location:253580
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
      PHA03247
      Location:134231
      PHA03247; large tegument protein UL36; Provisional
      cd17715
      Location:40123
      BRCT_polymerase_lambda; BRCT domain of DNA polymerase lambda and similar proteins
    3. XM_036161645.1XP_036017538.1  DNA polymerase lambda isoform X1

      Conserved Domains (3) summary
      cd00141
      Location:253580
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
      PHA03247
      Location:134231
      PHA03247; large tegument protein UL36; Provisional
      cd17715
      Location:40123
      BRCT_polymerase_lambda; BRCT domain of DNA polymerase lambda and similar proteins
    Support Center