U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    ERO1B endoplasmic reticulum oxidoreductase 1 beta [ Homo sapiens (human) ]

    Gene ID: 56605, updated on 5-Mar-2024

    Summary

    Official Symbol
    ERO1Bprovided by HGNC
    Official Full Name
    endoplasmic reticulum oxidoreductase 1 betaprovided by HGNC
    Primary source
    HGNC:HGNC:14355
    See related
    Ensembl:ENSG00000086619 MIM:615437; AllianceGenome:HGNC:14355
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERO1LB; Ero1beta
    Summary
    Enables thiol oxidase activity. Involved in protein folding in endoplasmic reticulum. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in stomach (RPKM 19.2), thyroid (RPKM 16.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ERO1B in Genome Data Viewer
    Location:
    1q42.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (236215101..236281958, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (235617345..235684232, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (236378401..236445258, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene meiotic recombination hotspot MSTM1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2813 Neighboring gene ACO2 pseudogene 2 Neighboring gene meiotic recombination hotspot MSTM2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1997 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:236306063-236306566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:236313713-236314481 Neighboring gene G protein-coupled receptor 137B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2814 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1999 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2817 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2816 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2818 Neighboring gene uncharacterized LOC124904561 Neighboring gene uncharacterized LOC124904562 Neighboring gene RNA, U2 small nuclear 70, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2819 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2000 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2820 Neighboring gene FKBP prolyl isomerase 3 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:236453609-236453847 Neighboring gene uncharacterized LOC124904852

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ11003, DKFZp779C1042, DKFZp779I0141

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-disulfide reductase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables thiol oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables unfolded protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in insulin processing TAS
    Traceable Author Statement
    more info
     
    involved_in protein folding TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein folding in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein folding in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ERO1-like protein beta
    Names
    ERO1-L-beta
    ERO1-like beta
    endoplasmic oxidoreductin-1-like protein B
    endoplasmic reticulum oxidoreductase beta
    endoplasmic reticulum oxidoreductin-1-like protein B
    oxidoreductin-1-L-beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019891.4NP_063944.3  ERO1-like protein beta precursor

      See identical proteins and their annotated locations for NP_063944.3

      Status: VALIDATED

      Source sequence(s)
      AL139162, AL450309, BC044573, BG723126, CR749523
      Consensus CDS
      CCDS31064.1
      UniProtKB/Swiss-Prot
      B4DF57, Q5T1H4, Q86YB8, Q8IZ11, Q9NR62
      UniProtKB/TrEMBL
      B2RD00
      Related
      ENSP00000346635.5, ENST00000354619.10
      Conserved Domains (1) summary
      pfam04137
      Location:56454
      ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      236215101..236281958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      235617345..235684232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)