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    hdac6 histone deacetylase 6 [ Danio rerio (zebrafish) ]

    Gene ID: 565482, updated on 19-Nov-2025
    Official Symbol
    hdac6provided by ZNC
    Official Full Name
    histone deacetylase 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3232
    See related
    Ensembl:ENSDARG00000008384 AllianceGenome:ZFIN:ZDB-GENE-030131-3232
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc31d02
    Summary
    Enables potassium ion binding activity; tubulin deacetylase activity; and zinc ion binding activity. Acts upstream of or within several processes, including hemopoiesis; regulation of tubulin deacetylation; and swimming behavior. Predicted to be part of histone deacetylase complex. Human ortholog(s) of this gene implicated in chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia and polycystic liver disease 1. Orthologous to human HDAC6 (histone deacetylase 6). [provided by Alliance of Genome Resources, Apr 2025]
    Orthologs
    human mouse all
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    See hdac6 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2025_04 current GRCz12tu (GCF_049306965.1) 8 NC_133183.1 (8927983..8979327, complement)
    RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 8 NC_007119.7 (7393435..7444466, complement)

    Chromosome 8 - NC_133183.1Genomic Context describing neighboring genes Neighboring gene ssu-2 homolog, related sequence 1 Neighboring gene selenoprotein H Neighboring gene histone H3-like centromeric protein A Neighboring gene proprotein convertase subtilisin/kexin type 1 inhibitor, like Neighboring gene LHFPL tetraspan subfamily member 4b Neighboring gene GATA binding protein 1b Neighboring gene cyclin dependent kinase 20

    Go to nucleotide: Graphics FASTA GenBank

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Related articles in PubMed

    1. Deciphering the Therapeutic Potential of Novel Pentyloxyamide-Based Class I, IIb HDAC Inhibitors against Therapy-Resistant Leukemia. Fischer F, et al. J Med Chem, 2024 Dec 12. PMID 39602240
    2. Structural insights into HDAC6 tubulin deacetylation and its selective inhibition. Miyake Y, et al. Nat Chem Biol, 2016 Sep. PMID 27454931
    3. Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Hai Y, et al. Nat Chem Biol, 2016 Sep. PMID 27454933, Free PMC Article
    4. Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors. Porter NJ, et al. Proc Natl Acad Sci U S A, 2017 Dec 19. PMID 29203661, Free PMC Article
    5. Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors. Sellmer A, et al. J Med Chem, 2018 Apr 26. PMID 29589441

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Histone Deacetylases Cooperate with NF-kappaB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury.
      Title: Histone Deacetylases Cooperate with NF-κB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury.
    2. Binding of inhibitors to active-site mutants of CD1, the enigmatic catalytic domain of histone deacetylase 6.
      Title: Binding of inhibitors to active-site mutants of CD1, the enigmatic catalytic domain of histone deacetylase 6.
    3. HDAC6 inhibition and the regulation of Prx1 activity may play a significant role in protecting retinal cells and in particular photoreceptors.
      Title: HDAC6 inhibition by tubastatin A is protective against oxidative stress in a photoreceptor cell line and restores visual function in a zebrafish model of inherited blindness.
    Submit: New GeneRIF Correction
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein lysine deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within definitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cellular component organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cellular component organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein deacetylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of tubulin deacetylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of tubulin deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within swimming behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tubulin deacetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane bounded cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    protein deacetylase HDAC6
    XP_009302026.1
    XP_009302027.1

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz12tu Primary Assembly

    Genomic

    1. NC_133183.1 Reference GRCz12tu Primary Assembly

      Range
      8927983..8979327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009303752.3 → XP_009302027.1  protein deacetylase HDAC6

      See identical proteins and their annotated locations for XP_009302027.1

      UniProtKB/TrEMBL
      A0A8M3BBK8, A7YT55, F8W4B7
      Related
      ENSDARP00000153983.1, ENSDART00000180659.1
      Conserved Domains (3) summary
      cd10003
      Location:448 → 798
      HDAC6-dom2; Histone deacetylase 6, domain 2
      cd11682
      Location:76 → 412
      HDAC6-dom1; Histone deacetylase 6, domain 1
      pfam02148
      Location:999 → 1061
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    2. XM_009303751.4 → XP_009302026.1  protein deacetylase HDAC6

      See identical proteins and their annotated locations for XP_009302026.1

      UniProtKB/TrEMBL
      A0A8M3BBK8, A7YT55, F8W4B7
      Related
      ENSDARP00000124246.1, ENSDART00000148993.3
      Conserved Domains (3) summary
      cd10003
      Location:448 → 798
      HDAC6-dom2; Histone deacetylase 6, domain 2
      cd11682
      Location:76 → 412
      HDAC6-dom1; Histone deacetylase 6, domain 1
      pfam02148
      Location:999 → 1061
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    Nucleotide Protein Strain
    Heading Accession and Version

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