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    Sec11a SEC11 homolog A, signal peptidase complex subunit [ Mus musculus (house mouse) ]

    Gene ID: 56529, updated on 22-Aug-2021

    Summary

    Official Symbol
    Sec11aprovided by MGI
    Official Full Name
    SEC11 homolog A, signal peptidase complex subunitprovided by MGI
    Primary source
    MGI:MGI:1929464
    See related
    Ensembl:ENSMUSG00000025724
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spc; 18kD; 18kDa; Sec11; Spc18; sid28; Sec11l1; sid2895; Sid2895p; 1810012E07Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 78.7), limb E14.5 (RPKM 45.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Sec11a in Genome Data Viewer
    Location:
    7; 7 D3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80565125..80597941, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80915379..80947550, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (88060265..88092436, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32112 Neighboring gene WD repeat domain 73 Neighboring gene neuromedin B Neighboring gene predicted gene, 51451 Neighboring gene predicted gene, 32178 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene Neighboring gene zinc finger protein 592

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    signal peptidase complex catalytic subunit SEC11A
    Names
    SEC11-like protein 1
    SPase 18 kDa subunit
    Sec11-like 1
    endopeptidase SP18
    microsomal signal peptidase 18 kDa subunit
    sid 2895
    signal peptidase complex (18kD)
    NP_064335.1
    XP_036009167.1
    XP_036009168.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019951.1NP_064335.1  signal peptidase complex catalytic subunit SEC11A

      See identical proteins and their annotated locations for NP_064335.1

      Status: PROVISIONAL

      Source sequence(s)
      AB025405
      Consensus CDS
      CCDS21401.1
      UniProtKB/Swiss-Prot
      Q9R0P6
      Related
      ENSMUSP00000026818.6, ENSMUST00000026818.12
      Conserved Domains (1) summary
      cl10465
      Location:38150
      Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      80565125..80597941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153275.1XP_036009168.1  signal peptidase complex catalytic subunit SEC11A isoform X2

    2. XM_036153274.1XP_036009167.1  signal peptidase complex catalytic subunit SEC11A isoform X1

      Conserved Domains (1) summary
      cl10465
      Location:38122
      Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...
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