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    Mpp6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) [ Mus musculus (house mouse) ]

    Gene ID: 56524, updated on 5-Aug-2018

    Summary

    Official Symbol
    Mpp6provided by MGI
    Official Full Name
    membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)provided by MGI
    Primary source
    MGI:MGI:1927340
    See related
    Ensembl:ENSMUSG00000038388 Vega:OTTMUSG00000035974
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P55t; Pals2
    Expression
    Broad expression in testis adult (RPKM 14.9), CNS E11.5 (RPKM 12.6) and 23 other tissues See more
    Orthologs

    Genomic context

    See Mpp6 in Genome Data Viewer
    Location:
    6 B2.3; 6 24.13 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (50110241..50198598)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (50060240..50148597)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 38805 Neighboring gene gasdermin E Neighboring gene oxysterol binding protein-like 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    guanylate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    MAGUK p55 subfamily member 6
    Names
    dlgh4 protein
    fibroblast growth factor-inducible protein 15
    membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 6)
    protein associated with Lin-7 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164733.1NP_001158205.1  MAGUK p55 subfamily member 6 isoform a

      See identical proteins and their annotated locations for NP_001158205.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AK144434, BC145364
      Consensus CDS
      CCDS51770.1
      UniProtKB/Swiss-Prot
      Q9JLB0
      UniProtKB/TrEMBL
      Q3UN60
      Related
      ENSMUSP00000038772.8, OTTMUSP00000050981, ENSMUST00000036225.14, OTTMUST00000092307
      Conserved Domains (5) summary
      smart00569
      Location:255
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12038
      Location:232292
      SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
      cd00992
      Location:132205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:57108
      L27; L27 domain
      cl27059
      Location:350540
      Guanylate_kin; Guanylate kinase
    2. NM_001164734.1NP_001158206.1  MAGUK p55 subfamily member 6 isoform a

      See identical proteins and their annotated locations for NP_001158206.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AK144434
      Consensus CDS
      CCDS51770.1
      UniProtKB/Swiss-Prot
      Q9JLB0
      UniProtKB/TrEMBL
      Q3UN60
      Related
      ENSMUSP00000125880.1, OTTMUSP00000050979, ENSMUST00000166318.7, OTTMUST00000092305
      Conserved Domains (5) summary
      smart00569
      Location:255
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12038
      Location:232292
      SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
      cd00992
      Location:132205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:57108
      L27; L27 domain
      cl27059
      Location:350540
      Guanylate_kin; Guanylate kinase
    3. NM_001361247.1NP_001348176.1  MAGUK p55 subfamily member 6 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC153618
      Conserved Domains (5) summary
      smart00569
      Location:255
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12038
      Location:218278
      SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
      cd00992
      Location:132205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:57108
      L27; L27 domain
      cl27059
      Location:336526
      Guanylate_kin; Guanylate kinase
    4. NM_001361248.1NP_001348177.1  MAGUK p55 subfamily member 6 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC153618
      Conserved Domains (5) summary
      smart00569
      Location:255
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12038
      Location:232292
      SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
      cd00992
      Location:132205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:57108
      L27; L27 domain
      cl27059
      Location:350540
      Guanylate_kin; Guanylate kinase
    5. NM_019939.2NP_064323.2  MAGUK p55 subfamily member 6 isoform b

      See identical proteins and their annotated locations for NP_064323.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AK144434
      Consensus CDS
      CCDS20128.1
      UniProtKB/Swiss-Prot
      Q9JLB0
      UniProtKB/TrEMBL
      B9EHZ5, Q3UN60
      Related
      ENSMUSP00000039314.8, OTTMUSP00000050980, ENSMUST00000036236.14, OTTMUST00000092306
      Conserved Domains (5) summary
      smart00569
      Location:255
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12038
      Location:218278
      SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
      cd00992
      Location:132205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:57108
      L27; L27 domain
      cl27059
      Location:336526
      Guanylate_kin; Guanylate kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      50110241..50198598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_008016.2: Suppressed sequence

      Description
      NM_008016.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Support Center