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    DNAJC12 DnaJ heat shock protein family (Hsp40) member C12 [ Homo sapiens (human) ]

    Gene ID: 56521, updated on 5-Mar-2024

    Summary

    Official Symbol
    DNAJC12provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C12provided by HGNC
    Primary source
    HGNC:HGNC:28908
    See related
    Ensembl:ENSG00000108176 MIM:606060; AllianceGenome:HGNC:28908
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JDP1; HPANBH4
    Summary
    This gene encodes a member of a subclass of the HSP40/DnaJ protein family. Members of this family of proteins are associated with complex assembly, protein folding, and export. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in adrenal (RPKM 18.5), liver (RPKM 12.0) and 15 other tissues See more
    Orthologs
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    Genomic context

    See DNAJC12 in Genome Data Viewer
    Location:
    10q21.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (67796669..67838188, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (68665111..68706704, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (69556427..69597946, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene tRNA-Ser (anticodon TGA) 1-1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3454 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3455 Neighboring gene ribosomal protein L21 pseudogene 92 Neighboring gene RNA, U6 small nuclear 1250, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:69578643-69579144 Neighboring gene RNA, 7SL, cytoplasmic 394, pseudogene Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3456 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3457 Neighboring gene Sharpr-MPRA regulatory region 12986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:69620921-69621442 Neighboring gene RNA, U6 small nuclear 523, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr10:69628867-69628993 Neighboring gene ribosomal protein L12 pseudogene 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dnaJ homolog subfamily C member 12
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 12
    J domain containing protein 1 (JDP1)
    J domain protein 1
    j domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021800.3NP_068572.1  dnaJ homolog subfamily C member 12 isoform a

      See identical proteins and their annotated locations for NP_068572.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (a).
      Source sequence(s)
      AF176012, AL133551, CB121724
      Consensus CDS
      CCDS7271.1
      UniProtKB/Swiss-Prot
      Q5JVQ1, Q9UKB2, Q9UKB3
      UniProtKB/TrEMBL
      Q6IAH1, S4R3E2
      Related
      ENSP00000225171.2, ENST00000225171.7
      Conserved Domains (2) summary
      COG2214
      Location:9164
      CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]
      pfam00226
      Location:1476
      DnaJ; DnaJ domain
    2. NM_201262.2NP_957714.1  dnaJ homolog subfamily C member 12 isoform b

      See identical proteins and their annotated locations for NP_957714.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences compared to variant 1. The resulting isoform (b) contains a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AF176013, AL133551, CB121724
      Consensus CDS
      CCDS7272.1
      UniProtKB/Swiss-Prot
      Q9UKB3
      Related
      ENSP00000343575.6, ENST00000339758.7
      Conserved Domains (1) summary
      pfam00226
      Location:1476
      DnaJ; DnaJ domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      67796669..67838188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      68665111..68706704 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)