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    Gabarap gamma-aminobutyric acid receptor associated protein [ Mus musculus (house mouse) ]

    Gene ID: 56486, updated on 18-Sep-2024

    Summary

    Official Symbol
    Gabarapprovided by MGI
    Official Full Name
    gamma-aminobutyric acid receptor associated proteinprovided by MGI
    Primary source
    MGI:MGI:1861742
    See related
    Ensembl:ENSMUSG00000018567 AllianceGenome:MGI:1861742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables microtubule binding activity. Acts upstream of or within microtubule cytoskeleton organization. Located in several cellular components, including cytoskeleton; smooth endoplasmic reticulum; and sperm midpiece. Part of microtubule associated complex. Is expressed in retina inner plexiform layer and spinal cord. Orthologous to human GABARAP (GABA type A receptor-associated protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 222.5), testis adult (RPKM 209.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Gabarap in Genome Data Viewer
    Location:
    11 B3; 11 42.95 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69882196..69885775)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69991370..69994949)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene claudin 7 Neighboring gene elongator acetyltransferase complex subunit 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69793405-69793588 Neighboring gene STARR-positive B cell enhancer ABC_E3967 Neighboring gene CTD nuclear envelope phosphatase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69804503-69804686 Neighboring gene STARR-positive B cell enhancer ABC_E2997 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69808904-69809245 Neighboring gene PHD finger protein 23 Neighboring gene dishevelled segment polarity protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GABA receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GABA receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GABA receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylethanolamine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylethanolamine binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylethanolamine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nitrogen starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extrinsic apoptotic signaling pathway via death domain receptors ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within microtubule cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of Rac protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in autophagosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in autophagosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in autophagosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in autophagosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    part_of microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in smooth endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm midpiece IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    gamma-aminobutyric acid receptor-associated protein
    Names
    GABA-A receptor-associated protein
    gamma-aminobutyric acid reseptor associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019749.4NP_062723.1  gamma-aminobutyric acid receptor-associated protein

      See identical proteins and their annotated locations for NP_062723.1

      Status: VALIDATED

      Source sequence(s)
      AL596185, AV029091
      Consensus CDS
      CCDS24928.1
      UniProtKB/Swiss-Prot
      B1AR49, Q9DCD6, Q9QUI7
      Related
      ENSMUSP00000018711.9, ENSMUST00000018711.15
      Conserved Domains (1) summary
      cd17232
      Location:2116
      Ubl_ATG8_GABARAP; ubiquitin-like (Ubl) domain found in gamma-aminobutyric acid receptor-associated protein (GABARAP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69882196..69885775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)