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    Sae1 SUMO1 activating enzyme subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 56459, updated on 23-Jun-2021

    Summary

    Official Symbol
    Sae1provided by MGI
    Official Full Name
    SUMO1 activating enzyme subunit 1provided by MGI
    Primary source
    MGI:MGI:1929264
    See related
    Ensembl:ENSMUSG00000052833
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A; AOS1; Sua1; Uble; HSPC1; Uble1a; HSPC140; AL033372; AW743391; D7Ertd177; D7Ertd177e; 2400010M20Rik; 2610044L12Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 52.3), placenta adult (RPKM 35.2) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sae1 in Genome Data Viewer
    Location:
    7 A2; 7 8.88 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (16054161..16121821, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16320236..16387896, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (16912403..16973134, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene InaF motif containing 1 Neighboring gene coiled-coil domain containing 9 Neighboring gene BCL2 binding component 3 Neighboring gene uncharacterized LOC118567473 Neighboring gene zinc finger CCCH-type containing 4 Neighboring gene transmembrane protein 160

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SUMO activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to SUMO activating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables small protein activating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-like modifier activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular protein modification process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein modification by small protein conjugation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of SUMO activating enzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of SUMO activating enzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    SUMO-activating enzyme subunit 1
    Names
    SUMO-1 activating enzyme subunit 1
    ubiquitin-like (sentrin) activating enzyme E1A
    ubiquitin-like 1 (sentrin) activating enzyme E1A
    ubiquitin-like 1 (sentrin) activating enzyme subunit 1
    ubiquitin-like 1-activating enzyme E1A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285891.1NP_001272820.1  SUMO-activating enzyme subunit 1 isoform a

      See identical proteins and their annotated locations for NP_001272820.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC164880, AK162789, BB838763, BC068164
      Consensus CDS
      CCDS20848.1
      UniProtKB/Swiss-Prot
      Q9R1T2
      Related
      ENSMUSP00000147409.2, ENSMUST00000210999.2
      Conserved Domains (2) summary
      cd01492
      Location:20345
      Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:23338
      ThiF; ThiF family
    2. NM_001285892.1NP_001272821.1  SUMO-activating enzyme subunit 1 isoform b

      See identical proteins and their annotated locations for NP_001272821.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC164880, AK011772, AK162789, BB838763
      Consensus CDS
      CCDS85221.1
      UniProtKB/Swiss-Prot
      Q9R1T2
      Related
      ENSMUSP00000147771.2, ENSMUST00000211741.2
      Conserved Domains (2) summary
      cd01492
      Location:20173
      Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:23171
      ThiF; ThiF family
    3. NM_019748.3NP_062722.1  SUMO-activating enzyme subunit 1 isoform a

      See identical proteins and their annotated locations for NP_062722.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC164880, BB838763, BC068164
      Consensus CDS
      CCDS20848.1
      UniProtKB/Swiss-Prot
      Q9R1T2
      Related
      ENSMUSP00000092409.4, ENSMUST00000094815.5
      Conserved Domains (2) summary
      cd01492
      Location:20345
      Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:23338
      ThiF; ThiF family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      16054161..16121821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250653.2XP_011248955.1  SUMO-activating enzyme subunit 1 isoform X1

      Conserved Domains (1) summary
      cd01492
      Location:20173
      Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
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