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    PRSS2 serine protease 2 [ Homo sapiens (human) ]

    Gene ID: 5645, updated on 8-Jul-2021

    Summary

    Official Symbol
    PRSS2provided by HGNC
    Official Full Name
    serine protease 2provided by HGNC
    Primary source
    HGNC:HGNC:9483
    See related
    Ensembl:ENSG00000275896 MIM:601564
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRY2; TRY8; TRYP2
    Summary
    This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]
    Orthologs
    NEW
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    Genomic context

    See PRSS2 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (142770970..142774560)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 (PATCHES) NW_003571040.1 (974014..977604)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene T cell receptor beta locus Neighboring gene T cell receptor beta variable 29-1 Neighboring gene serine protease 1 Neighboring gene PRSS3 pseudogene 1 Neighboring gene WBP1L pseudogene 1 Neighboring gene T cell receptor beta diversity 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.
    GeneReviews: Not available
    Hereditary pancreatitis Compare labs

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120 PubMed
    env Cleavage of HIV-1 gp120 with trypsin at residue 432 destroys CD4 binding PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC111183, MGC120174, MGC120175

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metalloendopeptidase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
     
    enables serine-type peptidase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in antimicrobial humoral response TAS
    Traceable Author Statement
    more info
     
    involved_in collagen catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in collagen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in collagen catabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in digestion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in extracellular matrix disassembly TAS
    Traceable Author Statement
    more info
     
    involved_in positive regulation of cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cell growth TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in azurophil granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular matrix TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    trypsin-2
    Names
    anionic trypsinogen
    protease serine 2 preproprotein
    protease, serine 2
    protease, serine, 2 (trypsin 2)
    trypsin II
    trypsinogen 2
    NP_001290343.1
    NP_002761.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_001333.2 

      Range
      624987..628610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    2. NG_008322.2 RefSeqGene

      Range
      5028..8618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001303414.2NP_001290343.1  trypsin-2 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_001290343.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC245427, BC005814, BC030260, CA867206, DQ846873
      Consensus CDS
      CCDS83235.1
      UniProtKB/TrEMBL
      A6XMV9, Q6PK75
      Related
      ENSP00000488437.1, ENST00000633969.1
      Conserved Domains (2) summary
      smart00020
      Location:23253
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:24256
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. NM_002770.4NP_002761.1  trypsin-2 isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_002761.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC245427, BC005814, BC030260, CA867206
      Consensus CDS
      CCDS83236.1
      UniProtKB/Swiss-Prot
      P07478
      UniProtKB/TrEMBL
      Q5NV56, Q6PK75
      Related
      ENSP00000488338.1, ENST00000539842.6
      Conserved Domains (2) summary
      smart00020
      Location:23239
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:24242
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RNA

    1. NR_130149.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an internal exon and uses an alternate splice acceptor site at an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC245427, BC005814, BC030260, CA867206, CA951033
      Related
      ENST00000618750.2

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      142770970..142774560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p13 ALT_REF_LOCI_1

    Genomic

    1. NT_187562.1 Reference GRCh38.p13 ALT_REF_LOCI_1

      Range
      793943..797533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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