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    Clip1 CAP-GLY domain containing linker protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 56430, updated on 2-Sep-2018

    Summary

    Official Symbol
    Clip1provided by MGI
    Official Full Name
    CAP-GLY domain containing linker protein 1provided by MGI
    Primary source
    MGI:MGI:1928401
    See related
    Ensembl:ENSMUSG00000049550 Vega:OTTMUSG00000025900
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rsn; CYLN1; C81039; Clip50; restin; CLIP170; AV017631; CLIP-170; mKIAA4046; 1110007I12Rik; 4631429H07Rik
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 10.9), CNS E18 (RPKM 9.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Clip1 in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (123577794..123684361, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (124029079..124134300, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene diablo, IAP-binding mitochondrial protein Neighboring gene microRNA 7647 Neighboring gene VPS33A CORVET/HOPS core subunit Neighboring gene zinc finger, CCHC domain containing 8 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4046

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport into plasma membrane raft IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with macropinosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    CAP-Gly domain-containing linker protein 1
    Names
    Clip 170
    Reed-Steinberg cell-espressed intermediate filament-associated protein
    cytoplasmic linker protein 170
    cytoplasmic linker protein 50
    restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291229.1NP_001278158.1  CAP-Gly domain-containing linker protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AC129569
      Consensus CDS
      CCDS71663.1
      UniProtKB/Swiss-Prot
      Q922J3
      Related
      ENSMUSP00000107190.1, OTTMUSP00000031630, ENSMUST00000111564.7, OTTMUST00000063831
      Conserved Domains (3) summary
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
      pfam15964
      Location:4131070
      CCCAP; Centrosomal colon cancer autoantigen protein family
      pfam16641
      Location:12931309
      CLIP1_ZNF; CLIP1 zinc knuckle
    2. NM_001347468.1NP_001334397.1  CAP-Gly domain-containing linker protein 1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has several in-frame differences compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC129569
      Consensus CDS
      CCDS84958.1
      UniProtKB/TrEMBL
      D3Z3M7
    3. NM_001359220.1NP_001346149.1  CAP-Gly domain-containing linker protein 1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC129569
      Conserved Domains (3) summary
      pfam01302
      Location:213277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:13671383
      CLIP1_ZNF; CLIP1 zinc knuckle
      cl25732
      Location:4041298
      SMC_N; RecF/RecN/SMC N terminal domain
    4. NM_001359221.1NP_001346150.1  CAP-Gly domain-containing linker protein 1 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC129569
      Conserved Domains (3) summary
      pfam01302
      Location:213277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:12911307
      CLIP1_ZNF; CLIP1 zinc knuckle
      cl25732
      Location:4041222
      SMC_N; RecF/RecN/SMC N terminal domain
    5. NM_001359222.1NP_001346151.1  CAP-Gly domain-containing linker protein 1 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC129569
      Conserved Domains (3) summary
      pfam01302
      Location:213277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:12561272
      CLIP1_ZNF; CLIP1 zinc knuckle
      cl25732
      Location:4041187
      SMC_N; RecF/RecN/SMC N terminal domain
    6. NM_001359223.1NP_001346152.1  CAP-Gly domain-containing linker protein 1 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC129569
      Conserved Domains (2) summary
      pfam01302
      Location:213277
      CAP_GLY; CAP-Gly domain
      cl25732
      Location:3511093
      SMC_N; RecF/RecN/SMC N terminal domain
    7. NM_001359224.1NP_001346153.1  CAP-Gly domain-containing linker protein 1 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC129569
      Conserved Domains (2) summary
      pfam01302
      Location:213277
      CAP_GLY; CAP-Gly domain
      cl25732
      Location:3691134
      SMC_N; RecF/RecN/SMC N terminal domain
    8. NM_019765.5NP_062739.2  CAP-Gly domain-containing linker protein 1 isoform a

      See identical proteins and their annotated locations for NP_062739.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC129569
      Consensus CDS
      CCDS19667.1
      UniProtKB/Swiss-Prot
      Q922J3
      Related
      ENSMUSP00000107192.2, OTTMUSP00000031629, ENSMUST00000111566.8, OTTMUST00000063830
      Conserved Domains (3) summary
      pfam05483
      Location:3441112
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:13691385
      CLIP1_ZNF; CLIP1 zinc knuckle

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      123577794..123684361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321025.1XP_017176514.1  CAP-Gly domain-containing linker protein 1 isoform X22

      Conserved Domains (3) summary
      pfam01302
      Location:213277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:13671383
      CLIP1_ZNF; CLIP1 zinc knuckle
      cl25732
      Location:4041298
      SMC_N; RecF/RecN/SMC N terminal domain
    2. XM_017321019.1XP_017176508.1  CAP-Gly domain-containing linker protein 1 isoform X9

    3. XM_006530424.3XP_006530487.1  CAP-Gly domain-containing linker protein 1 isoform X26

      Related
      ENSMUSP00000068241.5, OTTMUSP00000031631, ENSMUST00000063905.11, OTTMUST00000063832
      Conserved Domains (3) summary
      pfam05483
      Location:3441112
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:12981314
      CLIP1_ZNF; CLIP1 zinc knuckle
    4. XM_006530416.3XP_006530479.1  CAP-Gly domain-containing linker protein 1 isoform X10

      Conserved Domains (4) summary
      COG1196
      Location:3541140
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
      pfam01576
      Location:7591819
      Myosin_tail_1; Myosin tail
      pfam16641
      Location:21142130
      CLIP1_ZNF; CLIP1 zinc knuckle
    5. XM_017321030.1XP_017176519.1  CAP-Gly domain-containing linker protein 1 isoform X29

      Conserved Domains (3) summary
      pfam01302
      Location:213277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:12561272
      CLIP1_ZNF; CLIP1 zinc knuckle
      cl25732
      Location:4041187
      SMC_N; RecF/RecN/SMC N terminal domain
    6. XM_017321029.1XP_017176518.1  CAP-Gly domain-containing linker protein 1 isoform X28

    7. XM_006530423.3XP_006530486.1  CAP-Gly domain-containing linker protein 1 isoform X25

      Conserved Domains (3) summary
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
      pfam15964
      Location:4131070
      CCCAP; Centrosomal colon cancer autoantigen protein family
      pfam16641
      Location:13021318
      CLIP1_ZNF; CLIP1 zinc knuckle
    8. XM_006530419.3XP_006530482.1  CAP-Gly domain-containing linker protein 1 isoform X13

      Conserved Domains (4) summary
      PRK03918
      Location:350812
      PRK03918; chromosome segregation protein; Provisional
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
      pfam01576
      Location:7031763
      Myosin_tail_1; Myosin tail
      pfam16641
      Location:20582074
      CLIP1_ZNF; CLIP1 zinc knuckle
    9. XM_006530415.3XP_006530478.1  CAP-Gly domain-containing linker protein 1 isoform X8

      Conserved Domains (4) summary
      COG1196
      Location:3691160
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
      pfam01576
      Location:7791839
      Myosin_tail_1; Myosin tail
      pfam16641
      Location:21342150
      CLIP1_ZNF; CLIP1 zinc knuckle
    10. XM_017321028.1XP_017176517.1  CAP-Gly domain-containing linker protein 1 isoform X27

      Related
      ENSMUSP00000121425.1, OTTMUSP00000031658, ENSMUST00000137363.7, OTTMUST00000063862
      Conserved Domains (3) summary
      pfam01302
      Location:213277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:12911307
      CLIP1_ZNF; CLIP1 zinc knuckle
      cl25732
      Location:4041222
      SMC_N; RecF/RecN/SMC N terminal domain
    11. XM_017321020.1XP_017176509.1  CAP-Gly domain-containing linker protein 1 isoform X14

    12. XM_006530422.3XP_006530485.1  CAP-Gly domain-containing linker protein 1 isoform X20

      UniProtKB/TrEMBL
      D3Z2Z1
      Related
      ENSMUSP00000107186.1, OTTMUSP00000031656, ENSMUST00000111561.7, OTTMUST00000063860
      Conserved Domains (3) summary
      TIGR04523
      Location:3991149
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:14041420
      CLIP1_ZNF; CLIP1 zinc knuckle
    13. XM_017321023.1XP_017176512.1  CAP-Gly domain-containing linker protein 1 isoform X19

    14. XM_006530412.3XP_006530475.1  CAP-Gly domain-containing linker protein 1 isoform X5

      Conserved Domains (4) summary
      COG1196
      Location:3691195
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
      pfam01576
      Location:8141874
      Myosin_tail_1; Myosin tail
      pfam16641
      Location:21692185
      CLIP1_ZNF; CLIP1 zinc knuckle
    15. XM_006530413.3XP_006530476.1  CAP-Gly domain-containing linker protein 1 isoform X6

      Conserved Domains (4) summary
      COG1196
      Location:3531171
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
      pfam01576
      Location:7901850
      Myosin_tail_1; Myosin tail
      pfam16641
      Location:21452161
      CLIP1_ZNF; CLIP1 zinc knuckle
    16. XM_017321027.1XP_017176516.1  CAP-Gly domain-containing linker protein 1 isoform X24

    17. XM_017321026.1XP_017176515.1  CAP-Gly domain-containing linker protein 1 isoform X23

    18. XM_006530418.3XP_006530481.1  CAP-Gly domain-containing linker protein 1 isoform X12

      Conserved Domains (4) summary
      COG1196
      Location:3511089
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:9071804
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:20652081
      CLIP1_ZNF; CLIP1 zinc knuckle
    19. XM_006530417.3XP_006530480.1  CAP-Gly domain-containing linker protein 1 isoform X11

      Conserved Domains (4) summary
      COG1196
      Location:3511130
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
      pfam01576
      Location:7491809
      Myosin_tail_1; Myosin tail
      pfam16641
      Location:21042120
      CLIP1_ZNF; CLIP1 zinc knuckle
    20. XM_017321024.1XP_017176513.1  CAP-Gly domain-containing linker protein 1 isoform X21

    21. XM_006530414.3XP_006530477.1  CAP-Gly domain-containing linker protein 1 isoform X7

      Conserved Domains (4) summary
      TIGR02168
      Location:352941
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
      pfam01576
      Location:7521846
      Myosin_tail_1; Myosin tail
      pfam16641
      Location:21412157
      CLIP1_ZNF; CLIP1 zinc knuckle
    22. XM_006530421.3XP_006530484.1  CAP-Gly domain-containing linker protein 1 isoform X18

      UniProtKB/TrEMBL
      F8WIA1
      Related
      ENSMUSP00000031382.7, OTTMUSP00000031659, ENSMUST00000031382.13, OTTMUST00000063863
      Conserved Domains (3) summary
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
      pfam10174
      Location:4911141
      Cast; RIM-binding protein of the cytomatrix active zone
      pfam16641
      Location:14151431
      CLIP1_ZNF; CLIP1 zinc knuckle
    23. XM_017321022.1XP_017176511.1  CAP-Gly domain-containing linker protein 1 isoform X17

    24. XM_006530420.3XP_006530483.1  CAP-Gly domain-containing linker protein 1 isoform X16

      Conserved Domains (3) summary
      COG1196
      Location:4731355
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:14241440
      CLIP1_ZNF; CLIP1 zinc knuckle
    25. XM_006530411.3XP_006530474.1  CAP-Gly domain-containing linker protein 1 isoform X4

      Conserved Domains (4) summary
      COG1196
      Location:7261550
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:11412095
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:21712187
      CLIP1_ZNF; CLIP1 zinc knuckle
    26. XM_006530410.3XP_006530473.1  CAP-Gly domain-containing linker protein 1 isoform X3

      Conserved Domains (4) summary
      COG1196
      Location:7261550
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:351993
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:21732189
      CLIP1_ZNF; CLIP1 zinc knuckle
    27. XM_006530409.3XP_006530472.1  CAP-Gly domain-containing linker protein 1 isoform X2

      Conserved Domains (4) summary
      TIGR02168
      Location:351993
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
      pfam01576
      Location:8251885
      Myosin_tail_1; Myosin tail
      pfam16641
      Location:21782194
      CLIP1_ZNF; CLIP1 zinc knuckle
    28. XM_006530407.3XP_006530470.1  CAP-Gly domain-containing linker protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006530470.1

      Conserved Domains (4) summary
      TIGR02168
      Location:351993
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
      pfam01576
      Location:8251885
      Myosin_tail_1; Myosin tail
      pfam16641
      Location:21802196
      CLIP1_ZNF; CLIP1 zinc knuckle
    29. XM_017321017.1XP_017176506.1  CAP-Gly domain-containing linker protein 1 isoform X1

      Conserved Domains (4) summary
      TIGR02168
      Location:351993
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
      pfam01576
      Location:8251885
      Myosin_tail_1; Myosin tail
      pfam16641
      Location:21802196
      CLIP1_ZNF; CLIP1 zinc knuckle
    30. XM_011248233.2XP_011246535.1  CAP-Gly domain-containing linker protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011246535.1

      Conserved Domains (4) summary
      TIGR02168
      Location:351993
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
      pfam01576
      Location:8251885
      Myosin_tail_1; Myosin tail
      pfam16641
      Location:21802196
      CLIP1_ZNF; CLIP1 zinc knuckle
    31. XM_011248234.2XP_011246536.1  CAP-Gly domain-containing linker protein 1 isoform X15

      Conserved Domains (3) summary
      COG1196
      Location:7261550
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:351993
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:214277
      CAP_GLY; CAP-Gly domain
    32. XM_017321031.1XP_017176520.1  CAP-Gly domain-containing linker protein 1 isoform X30

      Conserved Domains (2) summary
      pfam01302
      Location:213277
      CAP_GLY; CAP-Gly domain
      cl25732
      Location:3691134
      SMC_N; RecF/RecN/SMC N terminal domain
    33. XM_017321032.1XP_017176521.1  CAP-Gly domain-containing linker protein 1 isoform X31

      Conserved Domains (2) summary
      pfam01302
      Location:213277
      CAP_GLY; CAP-Gly domain
      cl25732
      Location:3511093
      SMC_N; RecF/RecN/SMC N terminal domain
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