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    Hbs1l Hbs1-like (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 56422, updated on 13-Jul-2021

    Summary

    Official Symbol
    Hbs1lprovided by MGI
    Official Full Name
    Hbs1-like (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1891704
    See related
    Ensembl:ENSMUSG00000019977
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    eR; eRFS; AI326327; 2810035F15Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 10.6), CNS E11.5 (RPKM 9.0) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Hbs1l in Genome Data Viewer
    Location:
    10; 10 A3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (21171876..21244788)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (21295979..21368889)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (21015785..21088695)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33671 Neighboring gene predicted gene, 33728 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene RIKEN cDNA 4930455C13 gene Neighboring gene predicted gene, 33803 Neighboring gene aldehyde dehydrogenase 8 family, member A1 Neighboring gene FK506 binding protein 1a, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within translational elongation IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    HBS1-like protein
    Names
    eukaryotic release factor 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042593.1NP_001036058.1  HBS1-like protein isoform 2

      See identical proteins and their annotated locations for NP_001036058.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
      Source sequence(s)
      AK169281, BB016067, CJ082265
      Consensus CDS
      CCDS87970.1
      UniProtKB/TrEMBL
      Q3TGM7
      Related
      ENSMUSP00000020153.10, ENSMUST00000020153.10
      Conserved Domains (5) summary
      cd01883
      Location:257476
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
      COG5256
      Location:251679
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
      pfam08938
      Location:45119
      HBS1_N; HBS1 N-terminus
      cd16267
      Location:482564
      HBS1-like_II; Domain II of Hbs1-like proteins
      cd04093
      Location:569677
      HBS1_C_III; C-terminal domain of Hsp70 subfamily B suppressor 1 (HBS1)
    2. NM_001145209.2NP_001138681.1  HBS1-like protein isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate exon for its 3' coding region and 3' UTR, compared to variant (1). This results in a protein (isoform 3) with a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA432802, AC153557, BG081007, BQ558855, CF172634, CJ082265, CJ200386, CN530712, CV559390
      Consensus CDS
      CCDS48513.1
      UniProtKB/TrEMBL
      L7N209
      Related
      ENSMUSP00000090344.7, ENSMUST00000092674.14
      Conserved Domains (1) summary
      pfam08938
      Location:45119
      HBS1_N; HBS1 N-terminus
    3. NM_019702.2NP_062676.2  HBS1-like protein isoform 1

      See identical proteins and their annotated locations for NP_062676.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AK173091, BB016067, CJ082265
      Consensus CDS
      CCDS35862.1
      UniProtKB/Swiss-Prot
      Q69ZS7
      Related
      ENSMUSP00000151689.2, ENSMUST00000219915.2
      Conserved Domains (5) summary
      cd01883
      Location:260479
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
      COG5256
      Location:254682
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
      pfam08938
      Location:45119
      HBS1_N; HBS1 N-terminus
      cd16267
      Location:485567
      HBS1-like_II; Domain II of Hbs1-like proteins
      cd04093
      Location:572680
      HBS1_C_III; C-terminal domain of Hsp70 subfamily B suppressor 1 (HBS1)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      21171876..21244788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155898.1XP_036011791.1  HBS1-like protein isoform X3

      Conserved Domains (1) summary
      COG5256
      Location:94522
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    2. XM_006512803.5XP_006512866.1  HBS1-like protein isoform X1

      Conserved Domains (2) summary
      COG5256
      Location:254680
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
      pfam08938
      Location:46113
      HBS1_N; HBS1 N-terminus
    3. XM_036155897.1XP_036011790.1  HBS1-like protein isoform X2

      Conserved Domains (1) summary
      COG5256
      Location:94520
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    4. XM_036155896.1XP_036011789.1  HBS1-like protein isoform X2

      Conserved Domains (1) summary
      COG5256
      Location:94520
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    5. XM_006512805.4XP_006512868.1  HBS1-like protein isoform X2

      See identical proteins and their annotated locations for XP_006512868.1

      Conserved Domains (1) summary
      COG5256
      Location:94520
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]

    RNA

    1. XR_004936225.1 RNA Sequence

    2. XR_380070.1 RNA Sequence

    3. XR_004936226.1 RNA Sequence

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