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    Ppp4c protein phosphatase 4, catalytic subunit [ Mus musculus (house mouse) ]

    Gene ID: 56420, updated on 26-Sep-2022

    Summary

    Official Symbol
    Ppp4cprovided by MGI
    Official Full Name
    protein phosphatase 4, catalytic subunitprovided by MGI
    Primary source
    MGI:MGI:1891763
    See related
    Ensembl:ENSMUSG00000030697 AllianceGenome:MGI:1891763
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ppx; pp4; PP-X; PP4C; 1110002D08Rik
    Summary
    Predicted to enable lamin binding activity and protein serine/threonine phosphatase activity. Predicted to be involved in dephosphorylation and regulation of double-strand break repair via homologous recombination. Located in cytoplasm and nucleus. Part of protein phosphatase 4 complex. Is expressed in several structures, including brain; neural retina; olfactory epithelium; and thymus primordium. Orthologous to human PPP4C (protein phosphatase 4 catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 94.8), CNS E11.5 (RPKM 74.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ppp4c in Genome Data Viewer
    Location:
    7; 7 F3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126385038..126391729, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126785866..126792557, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene yippee like 3 Neighboring gene T-box 6 Neighboring gene aldolase A, fructose-bisphosphate Neighboring gene TLC domain containing 3B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NF-kappaB-inducing kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lamin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine phosphatase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein phosphatase 4 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein phosphatase 4 complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 4 catalytic subunit
    Names
    protein phosphatase X
    NP_001347393.1
    NP_062648.1
    XP_006508112.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360464.1NP_001347393.1  serine/threonine-protein phosphatase 4 catalytic subunit

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC124505
      Consensus CDS
      CCDS21844.1
      UniProtKB/TrEMBL
      A0A6P5Q134, A0A8C6N3I9, Q3UNF2
      Related
      ENSMUSP00000146245.2, ENSMUST00000206570.2
      Conserved Domains (1) summary
      cd07415
      Location:6290
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
    2. NM_019674.4NP_062648.1  serine/threonine-protein phosphatase 4 catalytic subunit

      See identical proteins and their annotated locations for NP_062648.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC124505
      Consensus CDS
      CCDS21844.1
      UniProtKB/Swiss-Prot
      P97470
      UniProtKB/TrEMBL
      A0A6P5Q134, A0A8C6N3I9, Q3UNF2
      Related
      ENSMUSP00000032936.7, ENSMUST00000032936.8
      Conserved Domains (1) summary
      cd07415
      Location:6290
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126385038..126391729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508049.2XP_006508112.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform X1

      See identical proteins and their annotated locations for XP_006508112.1

      Conserved Domains (1) summary
      cd07415
      Location:1211
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain