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    Diaph3 diaphanous related formin 3 [ Mus musculus (house mouse) ]

    Gene ID: 56419, updated on 31-Jan-2019

    Summary

    Official Symbol
    Diaph3provided by MGI
    Official Full Name
    diaphanous related formin 3provided by MGI
    Primary source
    MGI:MGI:1927222
    See related
    Ensembl:ENSMUSG00000022021
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dia2; Drf3; Diap3; p134MDia2; 4930417P13Rik
    Expression
    Biased expression in liver E14 (RPKM 4.9), liver E14.5 (RPKM 3.7) and 10 other tissues See more
    Orthologs

    Genomic context

    See Diaph3 in Genome Data Viewer
    Location:
    14; 14 E1
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (86655363..87141248, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (87056130..87540921, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32913 Neighboring gene predicted gene, 32969 Neighboring gene predicted gene, 33025 Neighboring gene predicted gene, 41223 Neighboring gene predicted gene, 41222 Neighboring gene ATP synthase subunit d, mitochondrial pseudogene Neighboring gene tudor domain containing 3 Neighboring gene NOP2 nucleolar protein homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4117

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Rho GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular component organization IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein diaphanous homolog 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019670.2NP_062644.1  protein diaphanous homolog 3

      See identical proteins and their annotated locations for NP_062644.1

      Status: VALIDATED

      Source sequence(s)
      AC158988, AF094519, BC085191
      Consensus CDS
      CCDS36990.1
      UniProtKB/Swiss-Prot
      Q9Z207
      Related
      ENSMUSP00000129420.1, ENSMUST00000168889.2
      Conserved Domains (3) summary
      pfam02181
      Location:615987
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:284471
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:96276
      Drf_GBD; Diaphanous GTPase-binding Domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      86655363..87141248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245123.2XP_011243425.1  protein diaphanous homolog 3 isoform X1

      Related
      ENSMUSP00000022599.7, ENSMUST00000022599.13
      Conserved Domains (3) summary
      pfam02181
      Location:604976
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:273460
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:85265
      Drf_GBD; Diaphanous GTPase-binding Domain
    2. XM_006519312.3XP_006519375.1  protein diaphanous homolog 3 isoform X2

      Conserved Domains (4) summary
      pfam02181
      Location:615987
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:284471
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:96276
      Drf_GBD; Diaphanous GTPase-binding Domain
      pfam09428
      Location:9961036
      DUF2011; Fungal protein of unknown function (DUF2011)
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