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    Nudt3 nudix (nucleotide diphosphate linked moiety X)-type motif 3 [ Mus musculus (house mouse) ]

    Gene ID: 56409, updated on 2-Oct-2021

    Summary

    Official Symbol
    Nudt3provided by MGI
    Official Full Name
    nudix (nucleotide diphosphate linked moiety X)-type motif 3provided by MGI
    Primary source
    MGI:MGI:1928484
    See related
    Ensembl:ENSMUSG00000024213
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dipp; Dipp1; AA960325; 1110011B09Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 71.3), adrenal adult (RPKM 66.7) and 28 other tissues See more
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    Genomic context

    See Nudt3 in Genome Data Viewer
    Location:
    17; 17 A3.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (27798356..27842426, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (27579382..27623452, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (27716336..27760397, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene high mobility group AT-hook 1 Neighboring gene expressed sequence AI413582 Neighboring gene ribosomal protein S10 Neighboring gene predicted gene 15420 Neighboring gene protein kinase C and casein kinase substrate in neurons 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables bis(5'-adenosyl)-hexaphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables bis(5'-adenosyl)-pentaphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables diphosphoinositol-polyphosphate diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables diphosphoinositol-polyphosphate diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables endopolyphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables inositol diphosphate pentakisphosphate diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables inositol diphosphate tetrakisphosphate diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables m7G(5')pppN diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in RNA decapping ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenosine 5'-(hexahydrogen pentaphosphate) catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in diadenosine hexaphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in diadenosine pentaphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in diphosphoinositol polyphosphate catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in diphosphoinositol polyphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    diphosphoinositol polyphosphate phosphohydrolase 1
    Names
    DIPP-1
    diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1
    NP_001277975.1
    NP_062811.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291046.1NP_001277975.1  diphosphoinositol polyphosphate phosphohydrolase 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' terminal exon compared to variant 1. The resulting protein (isoform 1) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC127341, AC131800, BU919402
      Consensus CDS
      CCDS70776.1
      UniProtKB/TrEMBL
      B2KF67
      Related
      ENSMUSP00000110536.2, ENSMUST00000114886.8
      Conserved Domains (1) summary
      cd04666
      Location:4105
      Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
    2. NM_019837.2NP_062811.1  diphosphoinositol polyphosphate phosphohydrolase 1 isoform 1

      See identical proteins and their annotated locations for NP_062811.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AC127341, AC131800
      Consensus CDS
      CCDS28566.1
      UniProtKB/Swiss-Prot
      Q9JI46
      Related
      ENSMUSP00000025050.6, ENSMUST00000025050.13
      Conserved Domains (1) summary
      cd04666
      Location:19134
      Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      27798356..27842426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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