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    Dusp14 dual specificity phosphatase 14 [ Mus musculus (house mouse) ]

    Gene ID: 56405, updated on 14-Oct-2018

    Summary

    Official Symbol
    Dusp14provided by MGI
    Official Full Name
    dual specificity phosphatase 14provided by MGI
    Primary source
    MGI:MGI:1927168
    See related
    Ensembl:ENSMUSG00000018648 Vega:OTTMUSG00000000968
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mkp6; MKP-L; D11Ertd395e; 1110014C10Rik; 2310042C07Rik
    Expression
    Broad expression in lung adult (RPKM 19.6), frontal lobe adult (RPKM 14.7) and 21 other tissues See more
    Orthologs

    Genomic context

    See Dusp14 in Genome Data Viewer
    Location:
    11 C; 11 51.29 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (84048041..84069256, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (83861547..83881859, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 Neighboring gene synergin, gamma Neighboring gene transcriptional adaptor 2A Neighboring gene acetyl-Coenzyme A carboxylase alpha Neighboring gene predicted gene 11437

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2)  1 citation

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    MAP kinase tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    dual specificity protein phosphatase 14
    Names
    MAP kinase phosphatase 6
    MAP kinase phsophatase 6
    MKP-6
    Mkp-1 like protein tyrosine phosphatase
    mitogen-activated protein kinase phosphatase 6
    NP_062793.2
    XP_006533859.1
    XP_006533860.1
    XP_006533861.1
    XP_006533862.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019819.3NP_062793.2  dual specificity protein phosphatase 14

      See identical proteins and their annotated locations for NP_062793.2

      Status: PROVISIONAL

      Source sequence(s)
      AK079362
      Consensus CDS
      CCDS25182.1
      UniProtKB/Swiss-Prot
      Q9JLY7
      UniProtKB/TrEMBL
      Q542U4
      Related
      ENSMUSP00000098271.4, OTTMUSP00000000917, ENSMUST00000100705.10, OTTMUST00000001898
      Conserved Domains (2) summary
      COG2453
      Location:47176
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      cd00127
      Location:26162
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      84048041..84069256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533796.3XP_006533859.1  dual specificity protein phosphatase 14 isoform X1

      See identical proteins and their annotated locations for XP_006533859.1

      UniProtKB/Swiss-Prot
      Q9JLY7
      UniProtKB/TrEMBL
      Q542U4
      Conserved Domains (2) summary
      COG2453
      Location:47176
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      cd00127
      Location:26162
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    2. XM_006533798.3XP_006533861.1  dual specificity protein phosphatase 14 isoform X1

      See identical proteins and their annotated locations for XP_006533861.1

      UniProtKB/Swiss-Prot
      Q9JLY7
      UniProtKB/TrEMBL
      Q542U4
      Related
      ENSMUSP00000130624.1, ENSMUST00000164891.7
      Conserved Domains (2) summary
      COG2453
      Location:47176
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      cd00127
      Location:26162
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    3. XM_006533797.3XP_006533860.1  dual specificity protein phosphatase 14 isoform X1

      See identical proteins and their annotated locations for XP_006533860.1

      UniProtKB/Swiss-Prot
      Q9JLY7
      UniProtKB/TrEMBL
      Q542U4
      Related
      ENSMUSP00000018792.5, OTTMUSP00000000916, ENSMUST00000018792.11, OTTMUST00000001897
      Conserved Domains (2) summary
      COG2453
      Location:47176
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      cd00127
      Location:26162
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    4. XM_006533799.3XP_006533862.1  dual specificity protein phosphatase 14 isoform X1

      See identical proteins and their annotated locations for XP_006533862.1

      UniProtKB/Swiss-Prot
      Q9JLY7
      UniProtKB/TrEMBL
      Q542U4
      Related
      ENSMUSP00000103736.1, OTTMUSP00000000919, ENSMUST00000108101.7, OTTMUST00000001900
      Conserved Domains (2) summary
      COG2453
      Location:47176
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      cd00127
      Location:26162
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
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