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    Dusp14 dual specificity phosphatase 14 [ Mus musculus (house mouse) ]

    Gene ID: 56405, updated on 3-Dec-2024

    Summary

    Official Symbol
    Dusp14provided by MGI
    Official Full Name
    dual specificity phosphatase 14provided by MGI
    Primary source
    MGI:MGI:1927168
    See related
    Ensembl:ENSMUSG00000018648 AllianceGenome:MGI:1927168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mkp6; MKP-L; D11Ertd395e; 1110014C10Rik; 2310042C07Rik
    Summary
    Predicted to enable MAP kinase tyrosine/serine/threonine phosphatase activity; myosin phosphatase activity; and protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human DUSP14 (dual specificity phosphatase 14). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 19.6), frontal lobe adult (RPKM 14.7) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Dusp14 in Genome Data Viewer
    Location:
    11 C; 11 51.29 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83938859..83960016, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84048033..84069256, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5256 Neighboring gene STARR-positive B cell enhancer ABC_E11769 Neighboring gene DExD box helicase 52 Neighboring gene synergin, gamma Neighboring gene STARR-positive B cell enhancer mm9_chr11:83845520-83845821 Neighboring gene STARR-seq mESC enhancer starr_30212 Neighboring gene transcriptional adaptor 2A Neighboring gene acetyl-Coenzyme A carboxylase alpha Neighboring gene predicted gene 11437

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5)  1 citation
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    dual specificity protein phosphatase 14
    Names
    MAP kinase phosphatase 6
    MAP kinase phsophatase 6
    Mkp-1 like protein tyrosine phosphatase
    mitogen-activated protein kinase phosphatase 6
    NP_001395670.1
    NP_001395671.1
    NP_001395672.1
    NP_001395673.1
    NP_001395674.1
    NP_001395675.1
    NP_062793.2
    XP_036012759.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001408741.1NP_001395670.1  dual specificity protein phosphatase 14

      Status: VALIDATED

      Source sequence(s)
      AL645615
      UniProtKB/Swiss-Prot
      Q9D715, Q9JLY7
      UniProtKB/TrEMBL
      Q542U4, Q7TPY1
      Related
      ENSMUSP00000103736.2, ENSMUST00000108101.8
    2. NM_001408742.1NP_001395671.1  dual specificity protein phosphatase 14

      Status: VALIDATED

      Source sequence(s)
      AL645615
      UniProtKB/Swiss-Prot
      Q9D715, Q9JLY7
      UniProtKB/TrEMBL
      Q542U4, Q7TPY1
    3. NM_001408743.1NP_001395672.1  dual specificity protein phosphatase 14

      Status: VALIDATED

      Source sequence(s)
      AL645615
      UniProtKB/Swiss-Prot
      Q9D715, Q9JLY7
      UniProtKB/TrEMBL
      Q542U4, Q7TPY1
      Related
      ENSMUSP00000130624.2, ENSMUST00000164891.8
    4. NM_001408744.1NP_001395673.1  dual specificity protein phosphatase 14

      Status: VALIDATED

      Source sequence(s)
      AL645615
      UniProtKB/Swiss-Prot
      Q9D715, Q9JLY7
      UniProtKB/TrEMBL
      Q542U4, Q7TPY1
      Related
      ENSMUSP00000018792.6, ENSMUST00000018792.12
    5. NM_001408745.1NP_001395674.1  dual specificity protein phosphatase 14

      Status: VALIDATED

      Source sequence(s)
      AL645615
      UniProtKB/Swiss-Prot
      Q9D715, Q9JLY7
      UniProtKB/TrEMBL
      Q542U4, Q7TPY1
    6. NM_001408746.1NP_001395675.1  dual specificity protein phosphatase 14

      Status: VALIDATED

      Source sequence(s)
      AL645615
      UniProtKB/Swiss-Prot
      Q9D715, Q9JLY7
      UniProtKB/TrEMBL
      Q542U4, Q7TPY1
    7. NM_019819.4NP_062793.2  dual specificity protein phosphatase 14

      See identical proteins and their annotated locations for NP_062793.2

      Status: VALIDATED

      Source sequence(s)
      AL645615
      Consensus CDS
      CCDS25182.1
      UniProtKB/Swiss-Prot
      Q9D715, Q9JLY7
      UniProtKB/TrEMBL
      Q542U4, Q7TPY1
      Related
      ENSMUSP00000098271.5, ENSMUST00000100705.11
      Conserved Domains (1) summary
      cd14572
      Location:20169
      DUSP14; dual specificity protein phosphatase 14

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      83938859..83960016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156866.1XP_036012759.1  dual specificity protein phosphatase 14 isoform X1

      UniProtKB/Swiss-Prot
      Q9D715, Q9JLY7
      UniProtKB/TrEMBL
      Q542U4, Q7TPY1
      Conserved Domains (1) summary
      cd14572
      Location:20169
      DUSP14; dual specificity protein phosphatase 14