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    Trip4 thyroid hormone receptor interactor 4 [ Mus musculus (house mouse) ]

    Gene ID: 56404, updated on 31-Jan-2019

    Summary

    Official Symbol
    Trip4provided by MGI
    Official Full Name
    thyroid hormone receptor interactor 4provided by MGI
    Primary source
    MGI:MGI:1928469
    See related
    Ensembl:ENSMUSG00000032386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Asc1; ASC-1; BB191711; 4930558E03Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.1), testis adult (RPKM 4.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Trip4 in Genome Data Viewer
    Location:
    9; 9 C
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (65828926..65908810, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (65676733..65756601, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene ornithine decarboxylase antizyme 2 Neighboring gene zinc finger protein 609 Neighboring gene predicted gene, 30089 Neighboring gene predicted gene, 30314 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene PCNA clamp associated factor Neighboring gene casein kinase 1, gamma 1 Neighboring gene sorting nexin 22 Neighboring gene peptidylprolyl isomerase B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-like protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    toxin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    activating signal cointegrator 1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    activating signal cointegrator 1
    Names
    TR-interacting protein 4
    TRIP-4
    thyroid receptor-interacting protein 4
    transcription coactivator Asc1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170907.1NP_001164378.1  activating signal cointegrator 1 isoform 2

      See identical proteins and their annotated locations for NP_001164378.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC151906, AK039024, AW121332, BB617447
      Consensus CDS
      CCDS52838.1
      UniProtKB/Swiss-Prot
      Q9QXN3
      Related
      ENSMUSP00000112866.1, ENSMUST00000122410.7
      Conserved Domains (2) summary
      cd06554
      Location:434525
      ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
      pfam06221
      Location:168216
      zf-C2HC5; Putative zinc finger motif, C2HC5-type
    2. NM_001357872.1NP_001344801.1  activating signal cointegrator 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AC151906
      Conserved Domains (2) summary
      cd06554
      Location:434547
      ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
      pfam06221
      Location:168216
      zf-C2HC5; Putative zinc finger motif, C2HC5-type
    3. NM_019797.4NP_062771.2  activating signal cointegrator 1 isoform 1

      See identical proteins and their annotated locations for NP_062771.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, also referred to as the testis specific form) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AC151906, AW121332
      Consensus CDS
      CCDS23298.1
      UniProtKB/Swiss-Prot
      Q9QXN3
      Related
      ENSMUSP00000112385.1, ENSMUST00000119245.7
      Conserved Domains (2) summary
      cd06554
      Location:434547
      ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
      pfam06221
      Location:168216
      zf-C2HC5; Putative zinc finger motif, C2HC5-type

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      65828926..65908810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511299.3XP_006511362.1  activating signal cointegrator 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9QXN3
      Related
      ENSMUSP00000113949.1, ENSMUST00000117083.1
      Conserved Domains (2) summary
      cd06554
      Location:434547
      ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
      pfam06221
      Location:168216
      zf-C2HC5; Putative zinc finger motif, C2HC5-type
    2. XM_006511298.3XP_006511361.1  activating signal cointegrator 1 isoform X1

      See identical proteins and their annotated locations for XP_006511361.1

      UniProtKB/Swiss-Prot
      Q9QXN3
      Conserved Domains (2) summary
      cd06554
      Location:434547
      ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
      pfam06221
      Location:168216
      zf-C2HC5; Putative zinc finger motif, C2HC5-type
    3. XM_006511296.3XP_006511359.1  activating signal cointegrator 1 isoform X1

      See identical proteins and their annotated locations for XP_006511359.1

      UniProtKB/Swiss-Prot
      Q9QXN3
      Conserved Domains (2) summary
      cd06554
      Location:434547
      ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
      pfam06221
      Location:168216
      zf-C2HC5; Putative zinc finger motif, C2HC5-type
    4. XM_017313492.1XP_017168981.1  activating signal cointegrator 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9QXN3
      Conserved Domains (2) summary
      cd06554
      Location:434547
      ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
      pfam06221
      Location:168216
      zf-C2HC5; Putative zinc finger motif, C2HC5-type
    5. XM_017313493.1XP_017168982.1  activating signal cointegrator 1 isoform X2

      UniProtKB/Swiss-Prot
      Q9QXN3
      Related
      ENSMUSP00000137304.1, ENSMUST00000179395.7
      Conserved Domains (2) summary
      cd06554
      Location:434525
      ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
      pfam06221
      Location:168216
      zf-C2HC5; Putative zinc finger motif, C2HC5-type
    6. XM_017313494.1XP_017168983.1  activating signal cointegrator 1 isoform X3

      Conserved Domains (2) summary
      pfam06221
      Location:168216
      zf-C2HC5; Putative zinc finger motif, C2HC5-type
      cl01020
      Location:434452
      ASCH; ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation, ...
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