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    Akap8 A kinase (PRKA) anchor protein 8 [ Mus musculus (house mouse) ]

    Gene ID: 56399, updated on 31-Jan-2019

    Summary

    Official Symbol
    Akap8provided by MGI
    Official Full Name
    A kinase (PRKA) anchor protein 8provided by MGI
    Primary source
    MGI:MGI:1928488
    See related
    Ensembl:ENSMUSG00000024045
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AKAP-8; AKAP95; AA673585; AU015639; 1200016A02Rik
    Summary
    This gene encodes a member of the A-kinase anchoring protein (AKAP) family. These proteins are characterized by their ability to bind to the R subunit of protein kinase A (PKA) and anchor the protein at different subcellular locations. This protein has been shown to regulate apoptosis and to be involved in palatogenesis. Knockdown of this gene has been associated with altered histone modifications and reduced expression of developmental genes in mouse embryonic stem cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 24.6), CNS E14 (RPKM 20.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Akap8 in Genome Data Viewer
    Location:
    17; 17 B1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (32303672..32321324, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (32440621..32458098, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene epoxide hydrolase 3 Neighboring gene bromodomain containing 4 Neighboring gene predicted gene 4432 Neighboring gene A kinase (PRKA) anchor protein 8-like Neighboring gene widely-interspaced zinc finger motifs

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    NF-kappaB binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase A regulatory subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell cycle G2/M phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to prostaglandin E stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic chromosome condensation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of histone deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of histone phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    condensed chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    female pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    A-kinase anchor protein 8
    Names
    A-kinase anchor protein 95 kDa

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357760.1NP_001344689.1  A-kinase anchor protein 8 isoform 2

      Status: REVIEWED

      Source sequence(s)
      BC060170, CT033751
      Conserved Domains (1) summary
      pfam04988
      Location:273433
      AKAP95; A-kinase anchoring protein 95 (AKAP95)
    2. NM_019774.5NP_062748.2  A-kinase anchor protein 8 isoform 1

      See identical proteins and their annotated locations for NP_062748.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the protein.
      Source sequence(s)
      AK004801, BC060170, BC060209
      Consensus CDS
      CCDS37555.1
      UniProtKB/Swiss-Prot
      Q9DBR0
      UniProtKB/TrEMBL
      Q059U9
      Related
      ENSMUSP00000002699.5, ENSMUST00000002699.5
      Conserved Domains (1) summary
      pfam04988
      Location:387547
      AKAP95; A-kinase anchoring protein 95 (AKAP95)

    RNA

    1. NR_131218.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC060170, BC060209
    2. NR_131219.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate internal exons and uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC054433, BC060170, BC060209

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      32303672..32321324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524664.3XP_006524727.1  A-kinase anchor protein 8 isoform X2

      Conserved Domains (1) summary
      pfam04988
      Location:273433
      AKAP95; A-kinase anchoring protein 95 (AKAP95)
    2. XM_006524665.3XP_006524728.1  A-kinase anchor protein 8 isoform X2

      See identical proteins and their annotated locations for XP_006524728.1

      Conserved Domains (1) summary
      pfam04988
      Location:273433
      AKAP95; A-kinase anchoring protein 95 (AKAP95)
    3. XM_006524666.3XP_006524729.1  A-kinase anchor protein 8 isoform X2

      See identical proteins and their annotated locations for XP_006524729.1

      Conserved Domains (1) summary
      pfam04988
      Location:273433
      AKAP95; A-kinase anchoring protein 95 (AKAP95)
    4. XM_006524663.3XP_006524726.1  A-kinase anchor protein 8 isoform X1

      Conserved Domains (1) summary
      pfam04988
      Location:362522
      AKAP95; A-kinase anchoring protein 95 (AKAP95)

    RNA

    1. XR_001782093.1 RNA Sequence

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