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    Shoc2 Shoc2, leucine rich repeat scaffold protein [ Mus musculus (house mouse) ]

    Gene ID: 56392, updated on 5-Aug-2018

    Summary

    Official Symbol
    Shoc2provided by MGI
    Official Full Name
    Shoc2, leucine rich repeat scaffold proteinprovided by MGI
    Primary source
    MGI:MGI:1927197
    See related
    Ensembl:ENSMUSG00000024976
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sur8; AU017287; mKIAA0862
    Expression
    Ubiquitous expression in CNS E18 (RPKM 12.8), placenta adult (RPKM 12.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Shoc2 in Genome Data Viewer
    Location:
    19; 19 D2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (53944232..54033280)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (54018796..54107768)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 20 Neighboring gene predicted gene, 41863 Neighboring gene predicted gene, 30990 Neighboring gene programmed cell death 4 Neighboring gene BBSome interacting protein 1 Neighboring gene adrenergic receptor, alpha 2a Neighboring gene predicted gene, 41865

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102442

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein phosphatase 1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    photoreceptor inner segment IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    photoreceptor outer segment membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein phosphatase type 1 complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    leucine-rich repeat protein SHOC-2
    Names
    Ras-binding protein SUR-8
    protein soc-2 homolog
    protein sur-8 homolog
    soc-2 (suppressor of clear) homolog
    soc-2-like protein
    suppressor of clear, C. elegans, homolog of

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168505.1NP_001161977.1  leucine-rich repeat protein SHOC-2

      See identical proteins and their annotated locations for NP_001161977.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC117612
      Consensus CDS
      CCDS29904.1
      UniProtKB/Swiss-Prot
      O88520
      Related
      ENSMUSP00000127932.1, ENSMUST00000169861.7
      Conserved Domains (2) summary
      sd00033
      Location:240262
      LRR_RI; leucine-rich repeat [structural motif]
      cl26793
      Location:115483
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    2. NM_001355242.1NP_001342171.1  leucine-rich repeat protein SHOC-2

      Status: VALIDATED

      Source sequence(s)
      AC117612
      Conserved Domains (2) summary
      sd00033
      Location:240262
      LRR_RI; leucine-rich repeat [structural motif]
      cl26793
      Location:115483
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    3. NM_019658.6NP_062632.2  leucine-rich repeat protein SHOC-2

      See identical proteins and their annotated locations for NP_062632.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC117612, AK146447
      Consensus CDS
      CCDS29904.1
      UniProtKB/Swiss-Prot
      O88520
      Related
      ENSMUSP00000025932.7, ENSMUST00000025932.7
      Conserved Domains (2) summary
      sd00033
      Location:240262
      LRR_RI; leucine-rich repeat [structural motif]
      cl26793
      Location:115483
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      53944232..54033280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527228.3XP_006527291.1  leucine-rich repeat protein SHOC-2 isoform X1

      See identical proteins and their annotated locations for XP_006527291.1

      UniProtKB/Swiss-Prot
      O88520
      Conserved Domains (2) summary
      sd00033
      Location:240262
      LRR_RI; leucine-rich repeat [structural motif]
      cl26793
      Location:115483
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    2. XM_011247299.2XP_011245601.1  leucine-rich repeat protein SHOC-2 isoform X1

      See identical proteins and their annotated locations for XP_011245601.1

      UniProtKB/Swiss-Prot
      O88520
      Conserved Domains (2) summary
      sd00033
      Location:240262
      LRR_RI; leucine-rich repeat [structural motif]
      cl26793
      Location:115483
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    3. XM_017318260.1XP_017173749.1  leucine-rich repeat protein SHOC-2 isoform X1

      UniProtKB/Swiss-Prot
      O88520
      Conserved Domains (2) summary
      sd00033
      Location:240262
      LRR_RI; leucine-rich repeat [structural motif]
      cl26793
      Location:115483
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
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