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    Stx5a syntaxin 5A [ Mus musculus (house mouse) ]

    Gene ID: 56389, updated on 23-Jun-2021

    Summary

    Official Symbol
    Stx5aprovided by MGI
    Official Full Name
    syntaxin 5Aprovided by MGI
    Primary source
    MGI:MGI:1928483
    See related
    Ensembl:ENSMUSG00000010110
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Stx5; D19Ertd627; D19Ertd627e; 0610031F24Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 35.3), ovary adult (RPKM 26.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Stx5a in Genome Data Viewer
    Location:
    19; 19 A
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8718788..8733006)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8741424..8755642)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (8815914..8830132)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 74 Neighboring gene RIKEN cDNA 1700092M07 gene Neighboring gene microRNA 6992 Neighboring gene RIKEN cDNA 1700023D09 gene Neighboring gene nuclear RNA export factor 1 Neighboring gene transmembrane protein 223

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables SNAP receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in early endosome to Golgi transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in vesicle fusion with Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of SNARE complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167799.1NP_001161271.1  syntaxin-5

      See identical proteins and their annotated locations for NP_001161271.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      BQ030996, CK389576, CN539678, DV649852
      Consensus CDS
      CCDS29542.2
      UniProtKB/Swiss-Prot
      Q8K1E0
      Related
      ENSMUSP00000134854.2, ENSMUST00000176381.8
      Conserved Domains (3) summary
      COG5325
      Location:94324
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15844
      Location:266338
      SNARE_syntaxin5; SNARE motif of syntaxin 5
      pfam11416
      Location:5374
      Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain
    2. NM_019829.4NP_062803.4  syntaxin-5

      See identical proteins and their annotated locations for NP_062803.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AC025794, BQ030996, CN539678, DV649852
      Consensus CDS
      CCDS29542.2
      UniProtKB/Swiss-Prot
      Q8K1E0
      Related
      ENSMUSP00000073136.8, ENSMUST00000073430.14
      Conserved Domains (3) summary
      COG5325
      Location:94324
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15844
      Location:266338
      SNARE_syntaxin5; SNARE motif of syntaxin 5
      pfam11416
      Location:5374
      Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      8718788..8733006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251000.2XP_030106860.1  syntaxin-5 isoform X1

      Conserved Domains (3) summary
      COG5325
      Location:94324
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15844
      Location:266338
      SNARE_syntaxin5; SNARE motif of syntaxin 5
      pfam11416
      Location:5374
      Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain
    2. XM_030250998.2XP_030106858.1  syntaxin-5 isoform X1

      Conserved Domains (3) summary
      COG5325
      Location:94324
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15844
      Location:266338
      SNARE_syntaxin5; SNARE motif of syntaxin 5
      pfam11416
      Location:5374
      Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain
    3. XM_030250999.2XP_030106859.1  syntaxin-5 isoform X1

      Conserved Domains (3) summary
      COG5325
      Location:94324
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15844
      Location:266338
      SNARE_syntaxin5; SNARE motif of syntaxin 5
      pfam11416
      Location:5374
      Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain
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