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    Fzr1 fizzy and cell division cycle 20 related 1 [ Mus musculus (house mouse) ]

    Gene ID: 56371, updated on 23-Jun-2021

    Summary

    Official Symbol
    Fzr1provided by MGI
    Official Full Name
    fizzy and cell division cycle 20 related 1provided by MGI
    Primary source
    MGI:MGI:1926790
    See related
    Ensembl:ENSMUSG00000020235
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fy; FZR; Fyr; Cdh1; FZR2; HCDH; HCDH1; AW108046
    Annotation information
    Note: CDH1 (GeneID 12550) and FZR1 (GeneID 56371) share the CDH1 symbol. CDH1 is sometimes used as an abbreviation for 'CDC20 homolog 1' which is an alternate name for the FZR1 gene and thus can be confused with the official symbol for cadherin 1 (CDH1). [16 Jul 2018]
    Expression
    Ubiquitous expression in ovary adult (RPKM 80.2), testis adult (RPKM 77.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Fzr1 in Genome Data Viewer
    Location:
    10; 10 C1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81202713..81214204, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81366879..81378370, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (80829624..80841115, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene high mobility group 20B Neighboring gene major facilitator superfamily domain containing 12 Neighboring gene RIKEN cDNA 4930404N11 gene Neighboring gene predicted gene, 48551 Neighboring gene deoxyhypusine hydroxylase/monooxygenase Neighboring gene microRNA 6913 Neighboring gene predicted gene, 48552

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables anaphase-promoting complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin ligase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin-protein transferase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in anaphase-promoting complex-dependent catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lens fiber cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proteolysis involved in cellular protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of meiotic nuclear division IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    fizzy-related protein homolog
    Names
    cdh1/Hct1 homolog
    cell division cycle 20 related 1
    fizzy/cell division cycle 20 related 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019757.1NP_062731.1  fizzy-related protein homolog

      See identical proteins and their annotated locations for NP_062731.1

      Status: PROVISIONAL

      Source sequence(s)
      AF083809
      Consensus CDS
      CCDS24057.1
      UniProtKB/Swiss-Prot
      Q9R1K5
      UniProtKB/TrEMBL
      Q3U3D4
      Related
      ENSMUSP00000114203.2, ENSMUST00000140901.8
      Conserved Domains (2) summary
      cd00200
      Location:193471
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:232269
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      81202713..81214204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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