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    Apip APAF1 interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 56369, updated on 31-Jan-2019

    Summary

    Official Symbol
    Apipprovided by MGI
    Official Full Name
    APAF1 interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1926788
    See related
    Ensembl:ENSMUSG00000010911
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APIP2; CGI-29; Mmrp19
    Expression
    Ubiquitous expression in heart adult (RPKM 17.9), limb E14.5 (RPKM 12.7) and 27 other tissues See more
    Orthologs

    Genomic context

    See Apip in Genome Data Viewer
    Location:
    2; 2 E2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (103073511..103092649)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (102913832..102932806)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene CD44 antigen Neighboring gene predicted gene, 34483 Neighboring gene pyruvate dehydrogenase complex, component X Neighboring gene predicted gene 13869 Neighboring gene ets homologous factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    methylthioribulose 1-phosphate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    methylthioribulose 1-phosphate dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    L-methionine salvage from methylthioadenosine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    L-methionine salvage from methylthioadenosine ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    pyroptosis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    methylthioribulose-1-phosphate dehydratase
    Names
    MTRu-1-P dehydratase
    monocyte macrophage 19
    monocyte/macrophage protein 19
    probable methylthioribulose-1-phosphate dehydratase
    NP_062709.3
    XP_006499989.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355473.1NP_001342402.1  methylthioribulose-1-phosphate dehydratase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL954375
      Conserved Domains (1) summary
      TIGR03328
      Location:27212
      salvage_mtnB; methylthioribulose-1-phosphate dehydratase
    2. NM_001355474.1NP_001342403.1  methylthioribulose-1-phosphate dehydratase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' end compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL954375
      Conserved Domains (1) summary
      cl00214
      Location:1154
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    3. NM_019735.4NP_062709.3  methylthioribulose-1-phosphate dehydratase isoform 1

      See identical proteins and their annotated locations for NP_062709.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK077705, AK145450, AV060627
      Consensus CDS
      CCDS16474.1
      UniProtKB/Swiss-Prot
      Q9WVQ5
      Related
      ENSMUSP00000011055.6, ENSMUST00000011055.6
      Conserved Domains (1) summary
      TIGR03328
      Location:27225
      salvage_mtnB; methylthioribulose-1-phosphate dehydratase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      103073511..103092649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499926.3XP_006499989.1  methylthioribulose-1-phosphate dehydratase isoform X1

      See identical proteins and their annotated locations for XP_006499989.1

      Conserved Domains (1) summary
      cl00214
      Location:140296
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    Reference GRCm38.p4 129S1/SvImJ

    Genomic

    1. NT_039223.3 Reference GRCm38.p4 129S1/SvImJ

      Range
      90415..109373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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