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    Acot9 acyl-CoA thioesterase 9 [ Mus musculus (house mouse) ]

    Gene ID: 56360, updated on 31-Jan-2019

    Summary

    Official Symbol
    Acot9provided by MGI
    Official Full Name
    acyl-CoA thioesterase 9provided by MGI
    Primary source
    MGI:MGI:1928939
    See related
    Ensembl:ENSMUSG00000025287
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    U8; p48; MTE-2; Acate2; C76421; MT-ACT48; 0610041P13Rik
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 15.0), placenta adult (RPKM 10.3) and 27 other tissues See more
    Orthologs

    Genomic context

    See Acot9 in Genome Data Viewer
    Location:
    X; X F3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (155262443..155297654)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (151697043..151732050)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene spermidine/spermine N1-acetyl transferase 1 Neighboring gene ribosomal protein L7 pseudogene Neighboring gene peroxiredoxin 4 Neighboring gene predicted gene, 39545

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    acetyl-CoA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acyl-CoA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    myristoyl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    palmitoyl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    acyl-coenzyme A thioesterase 9, mitochondrial
    Names
    acyl coenzyme A thioester hydrolase 2
    acyl-CoA thioester hydrolase 9
    acyl-Coenzyme A thioesterase 2, mitochondrial
    mitochondrial 48 kDa acyl-CoA thioester hydrolase 1
    mitochondrial acyl-CoA thioesterase
    protein U8

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313718.1NP_001300647.1  acyl-coenzyme A thioesterase 9, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' end, which causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AI854821, AK076513, BY288219
      Conserved Domains (1) summary
      cd03442
      Location:227347
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
    2. NM_019736.4NP_062710.2  acyl-coenzyme A thioesterase 9, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_062710.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AI854821, AK168713, BY288219
      Consensus CDS
      CCDS41187.1
      UniProtKB/Swiss-Prot
      Q9R0X4
      Related
      ENSMUSP00000026324.9, ENSMUST00000026324.9
      Conserved Domains (1) summary
      cd03442
      Location:286406
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      155262443..155297654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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