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    Ptges3 prostaglandin E synthase 3 [ Mus musculus (house mouse) ]

    Gene ID: 56351, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ptges3provided by MGI
    Official Full Name
    prostaglandin E synthase 3provided by MGI
    Primary source
    MGI:MGI:1929282
    See related
    Ensembl:ENSMUSG00000071072
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ptg; Teb; cPG; p23; Tebp; Ptges; cPGES; sid31; sid3177; 5730442A20Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 32.9), adrenal adult (RPKM 31.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ptges3 in Genome Data Viewer
    Location:
    10; 10 D3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127894851..127913123)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128058982..128077254)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (127496038..127514310)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene DNA primase, p49 subunit Neighboring gene nascent polypeptide-associated complex alpha polypeptide Neighboring gene predicted gene, 47438 Neighboring gene small nucleolar RNA, C/D box 59A Neighboring gene ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit Neighboring gene microRNA 677

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA polymerase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables prostaglandin-E synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables prostaglandin-E synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chaperone cofactor-dependent protein refolding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chaperone-mediated protein complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in chaperone-mediated protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within glucocorticoid receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glycogen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lung saccule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prostaglandin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within prostaglandin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prostaglandin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in telomerase holoenzyme complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in telomerase holoenzyme complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in telomerase holoenzyme complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in telomere maintenance via telomerase IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    part_of chaperone complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of telomerase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    prostaglandin E synthase 3
    Names
    cytosolic prostaglandin E2 synthase
    hsp90 co-chaperone
    p23 cochaperone
    progesterone receptor complex p23
    prostaglandin E synthase 3 (cytosolic)
    sid 3177
    telomerase binding protein, p23
    NP_062740.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019766.4NP_062740.1  prostaglandin E synthase 3

      See identical proteins and their annotated locations for NP_062740.1

      Status: PROVISIONAL

      Source sequence(s)
      AC131120
      Consensus CDS
      CCDS36087.1
      UniProtKB/Swiss-Prot
      Q9R0Q7
      Related
      ENSMUSP00000050292.8, ENSMUST00000052798.14
      Conserved Domains (1) summary
      cd00237
      Location:3109
      p23; p23 binds heat shock protein (Hsp)90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis.

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127894851..127913123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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