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    Net1 neuroepithelial cell transforming gene 1 [ Mus musculus (house mouse) ]

    Gene ID: 56349, updated on 19-Jul-2021

    Summary

    Official Symbol
    Net1provided by MGI
    Official Full Name
    neuroepithelial cell transforming gene 1provided by MGI
    Primary source
    MGI:MGI:1927138
    See related
    Ensembl:ENSMUSG00000021215
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mNET; Net1a; mNET1
    Expression
    Ubiquitous expression in large intestine adult (RPKM 25.9), limb E14.5 (RPKM 18.9) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Net1 in Genome Data Viewer
    Location:
    13; 13 A1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (3932018..3968220, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (3882018..3918220, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (3881807..3917466, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene calmodulin 4 Neighboring gene calmodulin 5 Neighboring gene tubulin, alpha-like 3 Neighboring gene urocortin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • 0610025H04Rik, 9530071N24Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    neuroepithelial cell-transforming gene 1 protein
    Names
    Net1 homolog
    guanine nucleotide regulatory protein (oncogene)
    rho guanine nucleotide exchange factor 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047159.2NP_001040624.1  neuroepithelial cell-transforming gene 1 protein isoform 2

      See identical proteins and their annotated locations for NP_001040624.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks part of the 5' coding region, uses an alternate 5'-terminal exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK082128, AK139921, BB598013
      Consensus CDS
      CCDS36583.1
      UniProtKB/Swiss-Prot
      Q9Z206
      UniProtKB/TrEMBL
      Q3USZ7
      Related
      ENSMUSP00000097529.5, ENSMUST00000099946.6
      Conserved Domains (3) summary
      smart00325
      Location:124300
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13224
      Location:314448
      PH_Net1; Neuroepithelial cell transforming 1 Pleckstrin homology (PH) domain
      pfam00169
      Location:333447
      PH; PH domain
    2. NM_019671.3NP_062645.2  neuroepithelial cell-transforming gene 1 protein isoform 1

      See identical proteins and their annotated locations for NP_062645.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC139323, AK082128, AK139921, CF167482
      Consensus CDS
      CCDS26216.1
      UniProtKB/Swiss-Prot
      Q9Z206
      UniProtKB/TrEMBL
      Q3USZ7
      Related
      ENSMUSP00000089464.5, ENSMUST00000091853.12
      Conserved Domains (3) summary
      smart00325
      Location:178354
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13224
      Location:368502
      PH_Net1; Neuroepithelial cell transforming 1 Pleckstrin homology (PH) domain
      pfam00169
      Location:387501
      PH; PH domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      3932018..3968220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247332.2XP_030103192.1  neuroepithelial cell-transforming gene 1 protein isoform X1

      Conserved Domains (2) summary
      smart00325
      Location:20196
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13224
      Location:210344
      PH_Net1; Neuroepithelial cell transforming 1 Pleckstrin homology (PH) domain
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