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    Eif3c eukaryotic translation initiation factor 3, subunit C [ Mus musculus (house mouse) ]

    Gene ID: 56347, updated on 31-Jan-2019

    Summary

    Official Symbol
    Eif3cprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 3, subunit Cprovided by MGI
    Primary source
    MGI:MGI:1926966
    See related
    Ensembl:ENSMUSG00000030738
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Xs; Xsl; 110kDa; Eif3s8; NipilA3; NIPIL(A3); 3230401O13Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 75.2), placenta adult (RPKM 74.3) and 28 other tissues See more

    Genomic context

    See Eif3c in Genome Data Viewer
    Location:
    7 69.14 cM; 7 F3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (126546911..126566366, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (133690425..133709880, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene Tu translation elongation factor, mitochondrial Neighboring gene ataxin 2-like Neighboring gene RIKEN cDNA 4930456A14 gene Neighboring gene ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease) Neighboring gene microRNA 7059 Neighboring gene apolipoprotein B receptor Neighboring gene interleukin 27

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (2) 
    • Chemically induced (ENU) (1) 
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    • Homologs of the Eif3c gene: The Eif3c gene is conserved in human, Rhesus monkey, dog, cow, rat, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
    • Orthologs

    Clone Names

    • MGC36637

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    translation initiation factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    positive regulation of mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translational initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    eukaryotic translation initiation factor 3 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    eukaryotic translation initiation factor 3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    eukaryotic translation initiation factor 3 complex, eIF3m IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 3 subunit C
    Names
    NIPI-like protein
    eIF3 p110
    eIF3c
    eukaryotic translation initiation factor 3 subunit 8
    eukaryotic translation initiation factor 3, subunit 8 (110 kDa)
    extra-toes spotting

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146200.1NP_666312.1  eukaryotic translation initiation factor 3 subunit C

      See identical proteins and their annotated locations for NP_666312.1

      Status: PROVISIONAL

      Source sequence(s)
      BC024855
      Consensus CDS
      CCDS21832.1
      UniProtKB/Swiss-Prot
      Q8R1B4
      Related
      ENSMUSP00000032992.4, ENSMUST00000032992.6
      Conserved Domains (2) summary
      smart00753
      Location:776864
      PAM; PCI/PINT associated module
      pfam05470
      Location:29703
      eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      126546911..126566366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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