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    Txnip thioredoxin interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 56338, updated on 21-Oct-2018

    Summary

    Official Symbol
    Txnipprovided by MGI
    Official Full Name
    thioredoxin interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1889549
    See related
    Ensembl:ENSMUSG00000038393 Vega:OTTMUSG00000021271
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    THIF; Tbp-2; VDUP1; Hyplip1; AA682105; 1200008J08Rik
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 279.2), lung adult (RPKM 241.9) and 24 other tissues See more
    Orthologs

    Genomic context

    See Txnip in Genome Data Viewer
    Location:
    3 F2.1; 3 41.93 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (96557957..96561857)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (96361880..96365780)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40100 Neighboring gene hemochromatosis type 2 (juvenile) Neighboring gene predicted gene 15441 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide G like Neighboring gene ankyrin repeat domain 34A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to tumor cell ISO
    Inferred from Sequence Orthology
    more info
     
    keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    platelet-derived growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    thioredoxin-interacting protein
    Names
    hyperlipidemia 1
    thioredoxin binding protein-2
    upregulated by 1,25-dihydroxyvitamin D-3
    vitamin D3 up-regulated protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009935.2NP_001009935.1  thioredoxin-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_001009935.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC122037
      Consensus CDS
      CCDS38555.1
      UniProtKB/Swiss-Prot
      Q8BG60
      Related
      ENSMUSP00000102710.2, OTTMUSP00000023522, ENSMUST00000074519.12, OTTMUST00000050413
      Conserved Domains (2) summary
      pfam02752
      Location:175299
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:10153
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    2. NM_023719.2NP_076208.2  thioredoxin-interacting protein isoform 2

      See identical proteins and their annotated locations for NP_076208.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AK089403, AK171456
      Consensus CDS
      CCDS17640.1
      UniProtKB/Swiss-Prot
      Q8BG60
      Related
      ENSMUSP00000041467.7, OTTMUSP00000023523, ENSMUST00000049093.7, OTTMUST00000050414
      Conserved Domains (2) summary
      pfam02752
      Location:174298
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:10152
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      96557957..96561857
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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