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    Mettl3 methyltransferase like 3 [ Mus musculus (house mouse) ]

    Gene ID: 56335, updated on 26-Oct-2021

    Summary

    Official Symbol
    Mettl3provided by MGI
    Official Full Name
    methyltransferase like 3provided by MGI
    Primary source
    MGI:MGI:1927165
    See related
    Ensembl:ENSMUSG00000022160
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    M6A; Spo8; 2310024F18Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 8.6), CNS E14 (RPKM 7.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mettl3 in Genome Data Viewer
    Location:
    14; 14 C2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52532298..52548555, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (52294841..52308741, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (52914516..52924799, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 8 Neighboring gene predicted gene, 26590 Neighboring gene RAB2B, member RAS oncogene family Neighboring gene predicted gene, 23758 Neighboring gene TOX high mobility group box family member 4 Neighboring gene spalt like transcription factor 2 Neighboring gene predicted gene, 53857 Neighboring gene predicted gene, 26328

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables S-adenosyl-L-methionine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA (N6-adenosine)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA (N6-adenosine)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA (N6-adenosine)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables mRNA (N6-adenosine)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in RNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within RNA methylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in RNA methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenosine to inosine editing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dosage compensation by inactivation of X chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in forebrain radial glial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gliogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mRNA methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA methylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mRNA modification ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NOT involved_in mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cap-independent translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in primary miRNA methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of RNA N6-methyladenosine methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RNA N6-methyladenosine methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    N6-adenosine-methyltransferase subunit METTL3
    Names
    MT-A70
    N6-adenosine-methyltransferase 70 kDa subunit
    m6a methyltransferase
    methyltransferase-like protein 3
    NP_062695.2
    XP_006519374.1
    XP_017171585.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019721.2NP_062695.2  N6-adenosine-methyltransferase subunit METTL3

      See identical proteins and their annotated locations for NP_062695.2

      Status: VALIDATED

      Source sequence(s)
      AK085189, BE979768, BY108113
      Consensus CDS
      CCDS27053.1
      UniProtKB/Swiss-Prot
      Q8C3P7
      UniProtKB/TrEMBL
      A0A0R4J041
      Related
      ENSMUSP00000022767.10, ENSMUST00000022767.16
      Conserved Domains (2) summary
      pfam05063
      Location:389550
      MT-A70; MT-A70
      pfam08619
      Location:1779
      Nha1_C; Alkali metal cation/H+ antiporter Nha1 C terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      52532298..52548555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519311.5XP_006519374.1  N6-adenosine-methyltransferase subunit METTL3 isoform X1

      Conserved Domains (1) summary
      pfam05063
      Location:234395
      MT-A70
    2. XM_017316096.3XP_017171585.1  N6-adenosine-methyltransferase subunit METTL3 isoform X1

      Conserved Domains (1) summary
      pfam05063
      Location:234395
      MT-A70

    RNA

    1. XR_001781134.3 RNA Sequence

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