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    Anapc7 anaphase promoting complex subunit 7 [ Mus musculus (house mouse) ]

    Gene ID: 56317, updated on 9-Dec-2024

    Summary

    Official Symbol
    Anapc7provided by MGI
    Official Full Name
    anaphase promoting complex subunit 7provided by MGI
    Primary source
    MGI:MGI:1929711
    See related
    Ensembl:ENSMUSG00000029466 AllianceGenome:MGI:1929711
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APC7
    Summary
    Predicted to enable enzyme-substrate adaptor activity and protein phosphatase binding activity. Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein polyubiquitination. Predicted to be located in heterochromatin; nucleus; and spindle. Predicted to be part of anaphase-promoting complex. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Used to study syndromic intellectual disability. Orthologous to human ANAPC7 (anaphase promoting complex subunit 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 22.5), adrenal adult (RPKM 18.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Anapc7 in Genome Data Viewer
    Location:
    5 F; 5 62.36 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122559646..122582978)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122422444..122444912)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14283 Neighboring gene GPN-loop GTPase 3 Neighboring gene predicted gene, 32853 Neighboring gene STARR-positive B cell enhancer ABC_E4787 Neighboring gene STARR-positive B cell enhancer ABC_E8077 Neighboring gene actin related protein 2/3 complex, subunit 3 Neighboring gene STARR-seq mESC enhancer starr_14286 Neighboring gene ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Neighboring gene STARR-positive B cell enhancer ABC_E10346 Neighboring gene STARR-seq mESC enhancer starr_14288 Neighboring gene predicted gene, 22965

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in anaphase-promoting complex-dependent catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K11-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein branched polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of anaphase-promoting complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in heterochromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    anaphase-promoting complex subunit 7
    Names
    cyclosome subunit 7
    prediabetic NOD sera-reactive autoantigen

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019805.5NP_062779.3  anaphase-promoting complex subunit 7

      See identical proteins and their annotated locations for NP_062779.3

      Status: VALIDATED

      Source sequence(s)
      AC113285
      Consensus CDS
      CCDS19649.1
      UniProtKB/Swiss-Prot
      Q3UBM7, Q8BSR2, Q91W13, Q9WVM3
      UniProtKB/TrEMBL
      D3YU58
      Related
      ENSMUSP00000031422.4, ENSMUST00000031422.10
      Conserved Domains (2) summary
      TIGR02917
      Location:145535
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:338368
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      122559646..122582978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165328.1XP_036021221.1  anaphase-promoting complex subunit 7 isoform X1

      UniProtKB/Swiss-Prot
      Q3UBM7, Q8BSR2, Q91W13, Q9WVM3
      UniProtKB/TrEMBL
      D3YU58
      Conserved Domains (2) summary
      TIGR02917
      Location:145535
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:338368
      TPR; TPR repeat [structural motif]