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    Sinhcaf SIN3-HDAC complex associated factor [ Mus musculus (house mouse) ]

    Gene ID: 56306, updated on 26-Sep-2022

    Summary

    Official Symbol
    Sinhcafprovided by MGI
    Official Full Name
    SIN3-HDAC complex associated factorprovided by MGI
    Primary source
    MGI:MGI:1929091
    See related
    Ensembl:ENSMUSG00000039985 AllianceGenome:MGI:1929091
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tera; Ppcs1; Fam60a; Pptcs1
    Summary
    Involved in negative regulation of cell differentiation and positive regulation of cell population proliferation. Predicted to be located in nucleus. Predicted to be part of Sin3 complex. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Orthologous to human SINHCAF (SIN3-HDAC complex associated factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 31.1), CNS E14 (RPKM 11.8) and 12 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Sinhcaf in Genome Data Viewer
    Location:
    6; 6 G3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (148822555..148847968, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (148921057..148946470, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene caprin family member 2 Neighboring gene predicted gene, 36762 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene RIKEN cDNA 3010003L21 gene Neighboring gene ES cell cis-regulatory motif 1b Neighboring gene predicted gene, 25539

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    SIN3-HDAC complex-associated factor
    Names
    family with sequence similarity 60, member A
    pluripotent cell-specific 1
    protein FAM60A
    teratocarcinoma expressed, serine rich

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355645.2NP_001342574.1  SIN3-HDAC complex-associated factor isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC140327
      Consensus CDS
      CCDS20713.1
      UniProtKB/Swiss-Prot
      Q3TLD2
      UniProtKB/TrEMBL
      A0A6P7R1Y0, A0A8C6HZP5
      Related
      ENSMUSP00000107188.2, ENSMUST00000081956.12
      Conserved Domains (1) summary
      pfam15396
      Location:2198
      FAM60A; Protein Family FAM60A
    2. NM_001361398.2NP_001348327.1  SIN3-HDAC complex-associated factor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140327
      Conserved Domains (1) summary
      pfam15396
      Location:296
      FAM60A; Protein Family FAM60A
    3. NM_001411256.1NP_001398185.1  SIN3-HDAC complex-associated factor isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC140327
    4. NM_001411257.1NP_001398186.1  SIN3-HDAC complex-associated factor isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC140327
    5. NM_001411258.1NP_001398187.1  SIN3-HDAC complex-associated factor isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC140327
    6. NM_001411259.1NP_001398188.1  SIN3-HDAC complex-associated factor isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC140327
    7. NM_001411260.1NP_001398189.1  SIN3-HDAC complex-associated factor isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC140327
    8. NM_001411261.1NP_001398190.1  SIN3-HDAC complex-associated factor isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC140327
    9. NM_001411262.1NP_001398191.1  SIN3-HDAC complex-associated factor isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC140327
    10. NM_001411263.1NP_001398192.1  SIN3-HDAC complex-associated factor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140327
    11. NM_001411264.1NP_001398193.1  SIN3-HDAC complex-associated factor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140327
    12. NM_001411265.1NP_001398194.1  SIN3-HDAC complex-associated factor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140327
    13. NM_019643.5NP_062617.2  SIN3-HDAC complex-associated factor isoform 1

      See identical proteins and their annotated locations for NP_062617.2

      Status: VALIDATED

      Source sequence(s)
      AC140327
      Consensus CDS
      CCDS20713.1
      UniProtKB/Swiss-Prot
      Q3TLD2, Q8C8M1
      UniProtKB/TrEMBL
      A0A6P7R1Y0, A0A8C6HZP5
      Related
      ENSMUSP00000050952.9, ENSMUST00000054080.15
      Conserved Domains (1) summary
      pfam15396
      Location:2198
      FAM60A; Protein Family FAM60A

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      148822555..148847968 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507074.5XP_006507137.1  SIN3-HDAC complex-associated factor isoform X1

      UniProtKB/Swiss-Prot
      Q3TLD2, Q8C8M1
      UniProtKB/TrEMBL
      A0A6P7R1Y0, A0A8C6HZP5
      Related
      ENSMUSP00000145487.2, ENSMUST00000204435.3
      Conserved Domains (1) summary
      pfam15396
      Location:2198
      FAM60A; Protein Family FAM60A
    2. XM_006507075.3XP_006507138.1  SIN3-HDAC complex-associated factor isoform X1

      UniProtKB/Swiss-Prot
      Q3TLD2, Q8C8M1
      UniProtKB/TrEMBL
      A0A6P7R1Y0, A0A8C6HZP5
      Related
      ENSMUSP00000107187.2, ENSMUST00000111562.8
      Conserved Domains (1) summary
      pfam15396
      Location:2198
      FAM60A; Protein Family FAM60A