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    Atl2 atlastin GTPase 2 [ Mus musculus (house mouse) ]

    Gene ID: 56298, updated on 31-Jan-2019

    Summary

    Official Symbol
    Atl2provided by MGI
    Official Full Name
    atlastin GTPase 2provided by MGI
    Primary source
    MGI:MGI:1929492
    See related
    Ensembl:ENSMUSG00000059811
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aip-2; Arl6ip2; AA407293; AV334690; 2010110I21Rik
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 8.7), thymus adult (RPKM 7.2) and 27 other tissues See more
    Orthologs

    Genomic context

    See Atl2 in Genome Data Viewer
    Location:
    17; 17 E3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (79848352..79896123, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (80247732..80295463, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41624 Neighboring gene predicted gene, 33055 Neighboring gene predicted gene, 41625 Neighboring gene eukaryotic translation initiation factor 3, subunit H pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein L-like Neighboring gene glutathione peroxidase 4, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum tubular network membrane organization ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum tubular network membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    atlastin-2
    Names
    ADP-ribosylation factor-like 6 interacting protein 2
    ADP-ribosylation factor-like protein 6-interacting protein 2
    ADP-ribosylation-like factor 6 interacting protein 2
    ARL-6 interacting protein-2
    NP_001273576.1
    NP_062691.3
    NP_835151.2
    XP_006524716.1
    XP_006524717.1
    XP_006524718.1
    XP_006524719.1
    XP_006524720.1
    XP_017173073.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286647.1NP_001273576.1  atlastin-2 isoform 3

      See identical proteins and their annotated locations for NP_001273576.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in an additional internal 5' UTR segment, translation initiation at a downstream start codon, and an alternate 3' coding region, compared to variant 1. The encoded protein (isoform 3) has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK008381, AK032050, AK038697, BM938279, BY244533
      UniProtKB/TrEMBL
      Q8BYP9, Q8C081, Q9D873
      Conserved Domains (1) summary
      cl21455
      Location:1170
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_001357752.1NP_001344681.1  atlastin-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC117261, BM938279
      Conserved Domains (1) summary
      pfam02263
      Location:70341
      GBP; Guanylate-binding protein, N-terminal domain
    3. NM_001357753.1NP_001344682.1  atlastin-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC117261, BM938279
      Conserved Domains (1) summary
      pfam02263
      Location:70341
      GBP; Guanylate-binding protein, N-terminal domain
    4. NM_019717.3NP_062691.3  atlastin-2 isoform 1

      See identical proteins and their annotated locations for NP_062691.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK008381, AK032050, AK038697, BC060501, BM938279
      Consensus CDS
      CCDS37700.1
      UniProtKB/Swiss-Prot
      Q6PA06
      UniProtKB/TrEMBL
      Q8BYP9, Q8C081, Q9D873
      Related
      ENSMUSP00000064758.5, ENSMUST00000068282.6
      Conserved Domains (1) summary
      pfam02263
      Location:70341
      GBP; Guanylate-binding protein, N-terminal domain
    5. NM_178050.4NP_835151.2  atlastin-2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon in the 5' region, which results in translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK008381, AK032050, AK038697, AK135988, BC060501, BM938279
      Consensus CDS
      CCDS37701.1
      UniProtKB/Swiss-Prot
      Q6PA06
      UniProtKB/TrEMBL
      E9QND8, Q8BYP9, Q8C081, Q9D873
      Related
      ENSMUSP00000108056.1, ENSMUST00000112437.7
      Conserved Domains (1) summary
      cl21455
      Location:1170
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      79848352..79896123 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524653.2XP_006524716.1  atlastin-2 isoform X1

      Conserved Domains (1) summary
      pfam02263
      Location:70341
      GBP; Guanylate-binding protein, N-terminal domain
    2. XM_006524657.3XP_006524720.1  atlastin-2 isoform X6

      Conserved Domains (1) summary
      cl21455
      Location:1170
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. XM_006524656.2XP_006524719.1  atlastin-2 isoform X4

      Conserved Domains (1) summary
      pfam02263
      Location:16287
      GBP; Guanylate-binding protein, N-terminal domain
    4. XM_006524655.3XP_006524718.1  atlastin-2 isoform X3

      Conserved Domains (1) summary
      pfam02263
      Location:70341
      GBP; Guanylate-binding protein, N-terminal domain
    5. XM_006524654.3XP_006524717.1  atlastin-2 isoform X2

      Conserved Domains (1) summary
      pfam02263
      Location:70341
      GBP; Guanylate-binding protein, N-terminal domain
    6. XM_017317584.1XP_017173073.1  atlastin-2 isoform X5

    RNA

    1. XR_001782092.1 RNA Sequence

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