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    Arl6 ADP-ribosylation factor-like 6 [ Mus musculus (house mouse) ]

    Gene ID: 56297, updated on 23-Jun-2021

    Summary

    Official Symbol
    Arl6provided by MGI
    Official Full Name
    ADP-ribosylation factor-like 6provided by MGI
    Primary source
    MGI:MGI:1927136
    See related
    Ensembl:ENSMUSG00000022722
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BBS; BBS3; 1110018H24Rik; 2210411E14Rik
    Expression
    Broad expression in CNS E18 (RPKM 9.1), CNS E14 (RPKM 7.1) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Arl6 in Genome Data Viewer
    Location:
    16; 16 C1.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (59433312..59459772, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (59612949..59639409, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (59613147..59639165, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700022E09 gene Neighboring gene ribosomal oxygenase 2 Neighboring gene beta-gamma crystallin domain containing 3 Neighboring gene RIKEN cDNA 4930547E14 gene Neighboring gene Eph receptor A6 Neighboring gene predicted gene 4660 Neighboring gene predicted gene 9017

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fat cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein ADP-ribosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within protein localization to ciliary membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein localization to cilium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to non-motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein transport from ciliary membrane to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within retina layer formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ADP-ribosylation factor-like protein 6
    Names
    ADP-ribosylation-like 6
    ADP-ribosylation-like factor homolog ARL6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347244.1NP_001334173.1  ADP-ribosylation factor-like protein 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154473, AK003778, AK158832
      Consensus CDS
      CCDS84248.1
      UniProtKB/Swiss-Prot
      O88848
      Related
      ENSMUSP00000097238.4, ENSMUST00000099646.10
    2. NM_019665.3NP_062639.3  ADP-ribosylation factor-like protein 6 isoform 1

      See identical proteins and their annotated locations for NP_062639.3

      Status: VALIDATED

      Source sequence(s)
      AK160666, BY279441, CO040545
      Consensus CDS
      CCDS28259.1
      UniProtKB/Swiss-Prot
      O88848
      UniProtKB/TrEMBL
      Q3TUM2
      Related
      ENSMUSP00000023405.10, ENSMUST00000023405.16
      Conserved Domains (2) summary
      smart00178
      Location:11181
      SAR; Sar1p-like members of the Ras-family of small GTPases
      cd04157
      Location:19180
      Arl6; Arf-like 6 (Arl6) GTPase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      59433312..59459772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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