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    Rassf1 Ras association (RalGDS/AF-6) domain family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 56289, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rassf1provided by MGI
    Official Full Name
    Ras association (RalGDS/AF-6) domain family member 1provided by MGI
    Primary source
    MGI:MGI:1928386
    See related
    Ensembl:ENSMUSG00000010067
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NO; Ra; RDA; Ras; 123F2; RDA32; REH3P; NORE2A; REH3P21; Rassf1A; Rassf1B; Rassf1C; AA536941; AU044980
    Expression
    Ubiquitous expression in lung adult (RPKM 22.7), testis adult (RPKM 20.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rassf1 in Genome Data Viewer
    Location:
    9; 9 F1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107428633..107439466)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107551434..107562267)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (107456987..107464591)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene NPR2 like, GATOR1 complex subunit Neighboring gene zinc finger, MYND domain containing 10 Neighboring gene predicted gene, 34106 Neighboring gene predicted gene 9917 Neighboring gene tumor suppressor 2, mitochondrial calcium regulator Neighboring gene hyaluronoglucosaminidase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ras association domain-containing protein 1
    Names
    123F protein
    RASSF1A tumor suppressor
    Ras association (RalGDS/AF-6) domain family 1
    protein 123F2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243748.1NP_001230677.1  ras association domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001230677.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK146736, AL672219, BY106916, CD564987
      Consensus CDS
      CCDS57699.1
      UniProtKB/Swiss-Prot
      Q99MK9
      UniProtKB/TrEMBL
      A9YZW8, Q3UIV8
      Related
      ENSMUSP00000091301.3, ENSMUST00000093786.9
      Conserved Domains (3) summary
      cd00029
      Location:52101
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd17218
      Location:130286
      RA_RASSF1; Ras-associating (RA) domain found in Ras-association domain-containing protein 1 (RASSF1)
      pfam16517
      Location:295334
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    2. NM_019713.4NP_062687.1  ras association domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_062687.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks the first two 5' coding exons, includes an alternate 5' coding exon, and initiates translation at an alternate start codon, compared to variant 1. The resulting protein (isoform 2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AF132851, AK146736, AL672219, CJ156337, CX224234
      Consensus CDS
      CCDS23494.1
      UniProtKB/Swiss-Prot
      Q99MK9
      UniProtKB/TrEMBL
      Q3UIV8
      Related
      ENSMUSP00000010211.5, ENSMUST00000010211.7
      Conserved Domains (2) summary
      cd17218
      Location:60216
      RA_RASSF1; Ras-associating (RA) domain found in Ras-association domain-containing protein 1 (RASSF1)
      pfam16517
      Location:225264
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      107428633..107439466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511770.4XP_006511833.1  ras association domain-containing protein 1 isoform X1

      Conserved Domains (2) summary
      pfam16517
      Location:145183
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl28922
      Location:1135
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    2. XM_036155142.1XP_036011035.1  ras association domain-containing protein 1 isoform X1

      Conserved Domains (2) summary
      pfam16517
      Location:145183
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl28922
      Location:1135
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
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