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    GKN1 gastrokine 1 [ Homo sapiens (human) ]

    Gene ID: 56287, updated on 22-Apr-2024

    Summary

    Official Symbol
    GKN1provided by HGNC
    Official Full Name
    gastrokine 1provided by HGNC
    Primary source
    HGNC:HGNC:23217
    See related
    Ensembl:ENSG00000169605 MIM:606402; AllianceGenome:HGNC:23217
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FOV; CA11; AMP18; BRICD1; foveolin
    Summary
    The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward stomach (RPKM 11425.3) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See GKN1 in Genome Data Viewer
    Location:
    2p13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (68974636..68980976)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (68987051..68993391)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (69201768..69208108)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15968 Neighboring gene gastrokine 3, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr2:69199258-69199490 Neighboring gene gastrokine 2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_59282 Neighboring gene ANTXR cell adhesion molecule 1 Neighboring gene microRNA 3126 Neighboring gene Sharpr-MPRA regulatory region 10320 Neighboring gene Sharpr-MPRA regulatory region 8391 Neighboring gene Sharpr-MPRA regulatory region 12475 Neighboring gene RNA, 5S ribosomal pseudogene 96

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC70354

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in digestion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in secretory granule IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    gastrokine-1
    Names
    18 kDa antrum mucosa protein
    BRICHOS domain containing 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019617.4NP_062563.4  gastrokine-1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC114802
      Consensus CDS
      CCDS1891.3
      UniProtKB/Swiss-Prot
      Q8IUA9, Q9NS71
      UniProtKB/TrEMBL
      A0A8I5KHR1, Q53YU7
      Related
      ENSP00000367172.3, ENST00000377938.4
      Conserved Domains (1) summary
      smart01039
      Location:54150
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      68974636..68980976
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      68987051..68993391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)