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    Actr8 ARP8 actin-related protein 8 [ Mus musculus (house mouse) ]

    Gene ID: 56249, updated on 26-Sep-2022

    Summary

    Official Symbol
    Actr8provided by MGI
    Official Full Name
    ARP8 actin-related protein 8provided by MGI
    Primary source
    MGI:MGI:1860775
    See related
    Ensembl:ENSMUSG00000015971 AllianceGenome:MGI:1860775
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARP8; 5730542K05Rik
    Summary
    Predicted to enable ATP binding activity. Predicted to be involved in double-strand break repair and regulation of transcription, DNA-templated. Predicted to act upstream of or within DNA recombination; DNA repair; and cell division. Predicted to be located in centrosome and nucleoplasm. Predicted to be part of Ino80 complex. Is expressed in several structures, including early conceptus; liver; metanephros; and oocyte. Orthologous to human ACTR8 (actin related protein 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.1), CNS E14 (RPKM 10.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Actr8 in Genome Data Viewer
    Location:
    14; 14 A3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (29700294..29717409)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (29978337..29995452)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S7 pseudogene Neighboring gene selenoprotein K Neighboring gene microRNA 6947 Neighboring gene interleukin 17 receptor B Neighboring gene choline dehydrogenase Neighboring gene predicted gene, 35449

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of DNA repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomere maintenance in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA strand elongation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of chromosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Ino80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Ino80 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    actin-related protein 8
    Names
    ARP8 actin-related protein 8 homolog
    actin-related protein 8 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027493.3NP_081769.2  actin-related protein 8

      See identical proteins and their annotated locations for NP_081769.2

      Status: VALIDATED

      Source sequence(s)
      CT009536
      Consensus CDS
      CCDS26891.1
      UniProtKB/Swiss-Prot
      Q8R2S9, Q9CYC4
      Related
      ENSMUSP00000016115.5, ENSMUST00000016115.6
      Conserved Domains (1) summary
      cl17037
      Location:160619
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      29700294..29717409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247897.1XP_030103757.1  actin-related protein 8 isoform X2

      UniProtKB/Swiss-Prot
      Q9CYC4
      Conserved Domains (1) summary
      cl17037
      Location:160619
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    2. XM_006519309.4XP_006519372.2  actin-related protein 8 isoform X1

      Conserved Domains (1) summary
      cl17037
      Location:160400
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    3. XM_036158765.1XP_036014658.1  actin-related protein 8 isoform X3

      Conserved Domains (1) summary
      cl17037
      Location:160400
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    4. XM_030247899.2XP_030103759.1  actin-related protein 8 isoform X5

      Conserved Domains (1) summary
      cl17037
      Location:5368
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    5. XM_030247898.2XP_030103758.1  actin-related protein 8 isoform X4

      Conserved Domains (1) summary
      cl17037
      Location:5150
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily