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    Patz1 POZ (BTB) and AT hook containing zinc finger 1 [ Mus musculus (house mouse) ]

    Gene ID: 56218, updated on 12-Aug-2018

    Summary

    Official Symbol
    Patz1provided by MGI
    Official Full Name
    POZ (BTB) and AT hook containing zinc finger 1provided by MGI
    Primary source
    MGI:MGI:1891832
    See related
    Ensembl:ENSMUSG00000020453 Vega:OTTMUSG00000000758
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mazr; Patz; Zfp278; AI447519; 8430401L15Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 44.7), ovary adult (RPKM 21.8) and 26 other tissues See more
    Orthologs

    Genomic context

    See Patz1 in Genome Data Viewer
    Location:
    11; 11 A1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (3289131..3309083)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (3190460..3208520)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene Sfi1 homolog, spindle assembly associated (yeast) Neighboring gene eukaryotic translation initiation factor 4E nuclear import factor 1 Neighboring gene developmentally regulated GTP binding protein 1 Neighboring gene predicted gene 11944 Neighboring gene phosphoinositide-3-kinase interacting protein 1 Neighboring gene LIM motif-containing protein kinase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    T cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    POZ-, AT hook-, and zinc finger-containing protein 1
    Names
    POZ-AT hook-zinc finger protein
    transcription factor (MAZ-related) MAZR
    zinc finger protein 278

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253690.1NP_001240619.1  POZ-, AT hook-, and zinc finger-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001240619.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) includes an additional exon that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AL671968, BC043035
      Consensus CDS
      CCDS56754.1
      UniProtKB/TrEMBL
      Q5NBZ1, Q80XS2
      Related
      ENSMUSP00000091103.5, OTTMUSP00000005187, ENSMUST00000093402.11, OTTMUST00000011105
      Conserved Domains (6) summary
      COG5048
      Location:381451
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:329406
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:357377
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:30159
      BTB; BTB/POZ domain
      pfam13465
      Location:369394
      zf-H2C2_2; Zinc-finger double domain
      pfam13912
      Location:442467
      zf-C2H2_6; C2H2-type zinc finger
    2. NM_001253691.1NP_001240620.1  POZ-, AT hook-, and zinc finger-containing protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) includes an additional exon that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AL671968, BC043035, CA327687
      UniProtKB/TrEMBL
      Q80XS2
      Related
      ENSMUSP00000092043.3, OTTMUSP00000000691, ENSMUST00000094471.9, OTTMUST00000001448
      Conserved Domains (4) summary
      COG5189
      Location:379436
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:357377
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:30159
      BTB; BTB/POZ domain
      pfam13465
      Location:369394
      zf-H2C2_2; Zinc-finger double domain
    3. NM_019574.3NP_062520.1  POZ-, AT hook-, and zinc finger-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_062520.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL671968
      Consensus CDS
      CCDS24356.1
      UniProtKB/TrEMBL
      Q9JMG9
      Related
      ENSMUSP00000050684.6, OTTMUSP00000000689, ENSMUST00000057089.12, OTTMUST00000001446
      Conserved Domains (6) summary
      COG5189
      Location:379436
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:357377
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:30159
      BTB; BTB/POZ domain
      pfam13465
      Location:369394
      zf-H2C2_2; Zinc-finger double domain
      pfam13912
      Location:442467
      zf-C2H2_6; C2H2-type zinc finger
      pfam16637
      Location:492558
      zf-C2H2_assoc3; Putative zinc-finger between two C2H2 zinc-fingers on Patz

    RNA

    1. NR_045108.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon and includes two additional internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, as found in variant 1.
      Source sequence(s)
      AL671968, BC043035, CJ106364
      Related
      ENSMUST00000134089.7, OTTMUST00000001449
    2. NR_045109.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, as found in variant 1.
      Source sequence(s)
      AK018372, BC043035, CJ106364
      Related
      ENSMUST00000101644.9

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      3289131..3309083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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