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    Rev1 REV1, DNA directed polymerase [ Mus musculus (house mouse) ]

    Gene ID: 56210, updated on 5-Aug-2018

    Summary

    Official Symbol
    Rev1provided by MGI
    Official Full Name
    REV1, DNA directed polymeraseprovided by MGI
    Primary source
    MGI:MGI:1929074
    See related
    Ensembl:ENSMUSG00000026082 Vega:OTTMUSG00000049485
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rev1l; AU022044; 1110027I23Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 8.2), CNS E14 (RPKM 7.3) and 27 other tissues See more
    Orthologs

    Genomic context

    See Rev1 in Genome Data Viewer
    Location:
    1; 1 B
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (38052786..38129920, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (38109631..38186507, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 9 Neighboring gene eukaryotic translation initiation factor 5B Neighboring gene predicted gene, 34448 Neighboring gene predicted gene 5099 Neighboring gene AF4/FMR2 family, member 3 Neighboring gene predicted gene 16150

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC66950

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    deoxycytidyl transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    error-prone translesion synthesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    DNA repair protein REV1
    Names
    REV1 homolog
    rev1-like terminal deoxycytidyl transferase
    NP_062516.2
    XP_006496216.1
    XP_006496217.1
    XP_006496218.1
    XP_006496219.1
    XP_006496221.1
    XP_006496224.1
    XP_006496225.1
    XP_006496227.1
    XP_017177320.1
    XP_017177322.1
    XP_017177324.1
    XP_017177325.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359287.1NP_001346216.1  DNA repair protein REV1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114583
      Conserved Domains (3) summary
      cd01701
      Location:16333
      PolY_Rev1; DNA polymerase Rev1
      pfam14377
      Location:449568
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:643759
      REV1_C; DNA repair protein REV1 C-terminal domain
    2. NM_001359288.1NP_001346217.1  DNA repair protein REV1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC114583
      Conserved Domains (3) summary
      pfam14377
      Location:417536
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:611727
      REV1_C; DNA repair protein REV1 C-terminal domain
      cl25410
      Location:1301
      PolY; Y-family of DNA polymerases
    3. NM_019570.4NP_062516.2  DNA repair protein REV1 isoform 1

      See identical proteins and their annotated locations for NP_062516.2

      Status: VALIDATED

      Source sequence(s)
      AK048838, BC058093
      Consensus CDS
      CCDS14899.1
      UniProtKB/Swiss-Prot
      Q920Q2
      Related
      ENSMUSP00000027251.6, OTTMUSP00000068279, ENSMUST00000027251.11
      Conserved Domains (5) summary
      cd01701
      Location:346822
      PolY_Rev1; DNA polymerase Rev1
      PRK14133
      Location:417831
      PRK14133; DNA polymerase IV; Provisional
      smart00292
      Location:48118
      BRCT; breast cancer carboxy-terminal domain
      pfam14377
      Location:9381057
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:11281248
      REV1_C; DNA repair protein REV1 C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      38052786..38129920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496155.3XP_006496218.1  DNA repair protein REV1 isoform X3

      Conserved Domains (5) summary
      cd01701
      Location:403869
      PolY_Rev1; DNA polymerase Rev1
      PRK14133
      Location:464878
      PRK14133; DNA polymerase IV; Provisional
      smart00292
      Location:105175
      BRCT; breast cancer carboxy-terminal domain
      pfam14377
      Location:9851104
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:11751295
      REV1_C; DNA repair protein REV1 C-terminal domain
    2. XM_006496154.3XP_006496217.1  DNA repair protein REV1 isoform X2

      Conserved Domains (6) summary
      cd01701
      Location:403878
      PolY_Rev1; DNA polymerase Rev1
      PRK14133
      Location:474887
      PRK14133; DNA polymerase IV; Provisional
      smart00292
      Location:105175
      BRCT; breast cancer carboxy-terminal domain
      pfam14377
      Location:9941113
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:11841304
      REV1_C; DNA repair protein REV1 C-terminal domain
      cl21456
      Location:487535
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    3. XM_006496153.3XP_006496216.1  DNA repair protein REV1 isoform X1

      Conserved Domains (5) summary
      cd01701
      Location:403879
      PolY_Rev1; DNA polymerase Rev1
      PRK14133
      Location:474888
      PRK14133; DNA polymerase IV; Provisional
      smart00292
      Location:105175
      BRCT; breast cancer carboxy-terminal domain
      pfam14377
      Location:9951114
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:11851305
      REV1_C; DNA repair protein REV1 C-terminal domain
    4. XM_006496156.3XP_006496219.1  DNA repair protein REV1 isoform X4

      Conserved Domains (5) summary
      cd01701
      Location:361837
      PolY_Rev1; DNA polymerase Rev1
      PRK14133
      Location:432846
      PRK14133; DNA polymerase IV; Provisional
      smart00292
      Location:63133
      BRCT; breast cancer carboxy-terminal domain
      pfam14377
      Location:9531072
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:11431263
      REV1_C; DNA repair protein REV1 C-terminal domain
    5. XM_006496158.2XP_006496221.1  DNA repair protein REV1 isoform X5

      See identical proteins and their annotated locations for XP_006496221.1

      UniProtKB/Swiss-Prot
      Q920Q2
      Conserved Domains (5) summary
      cd01701
      Location:346822
      PolY_Rev1; DNA polymerase Rev1
      PRK14133
      Location:417831
      PRK14133; DNA polymerase IV; Provisional
      smart00292
      Location:48118
      BRCT; breast cancer carboxy-terminal domain
      pfam14377
      Location:9381057
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:11281248
      REV1_C; DNA repair protein REV1 C-terminal domain
    6. XM_006496162.2XP_006496225.1  DNA repair protein REV1 isoform X7

      See identical proteins and their annotated locations for XP_006496225.1

      Conserved Domains (3) summary
      pfam14377
      Location:417536
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:611727
      REV1_C; DNA repair protein REV1 C-terminal domain
      cl25410
      Location:1301
      PolY; Y-family of DNA polymerases
    7. XM_006496161.2XP_006496224.1  DNA repair protein REV1 isoform X6

      Conserved Domains (3) summary
      cd01701
      Location:16333
      PolY_Rev1; DNA polymerase Rev1
      pfam14377
      Location:449568
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:643759
      REV1_C; DNA repair protein REV1 C-terminal domain
    8. XM_017321831.1XP_017177320.1  DNA repair protein REV1 isoform X6

      Conserved Domains (3) summary
      cd01701
      Location:16333
      PolY_Rev1; DNA polymerase Rev1
      pfam14377
      Location:449568
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:643759
      REV1_C; DNA repair protein REV1 C-terminal domain
    9. XM_017321833.1XP_017177322.1  DNA repair protein REV1 isoform X7

      Conserved Domains (3) summary
      pfam14377
      Location:417536
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:611727
      REV1_C; DNA repair protein REV1 C-terminal domain
      cl25410
      Location:1301
      PolY; Y-family of DNA polymerases
    10. XM_017321835.1XP_017177324.1  DNA repair protein REV1 isoform X7

      Conserved Domains (3) summary
      pfam14377
      Location:417536
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:611727
      REV1_C; DNA repair protein REV1 C-terminal domain
      cl25410
      Location:1301
      PolY; Y-family of DNA polymerases
    11. XM_017321836.1XP_017177325.1  DNA repair protein REV1 isoform X6

      Conserved Domains (3) summary
      cd01701
      Location:16333
      PolY_Rev1; DNA polymerase Rev1
      pfam14377
      Location:449568
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:643759
      REV1_C; DNA repair protein REV1 C-terminal domain
    12. XM_006496164.2XP_006496227.1  DNA repair protein REV1 isoform X7

      See identical proteins and their annotated locations for XP_006496227.1

      Conserved Domains (3) summary
      pfam14377
      Location:417536
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:611727
      REV1_C; DNA repair protein REV1 C-terminal domain
      cl25410
      Location:1301
      PolY; Y-family of DNA polymerases
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