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    Ddx21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 [ Mus musculus (house mouse) ]

    Gene ID: 56200, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ddx21provided by MGI
    Official Full Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 21provided by MGI
    Primary source
    MGI:MGI:1860494
    See related
    Ensembl:ENSMUSG00000020075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI255159; AL022742; D10Wsu42e; D10Ertd645e
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 23.3), liver E14 (RPKM 22.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See Ddx21 in Genome Data Viewer
    Location:
    10 B4; 10 32.43 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (62580247..62602316, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (62042995..62065046, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene serglycin Neighboring gene KIF1 binding protein Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 Neighboring gene storkhead box 1 Neighboring gene crumbs homolog 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Chemically induced (ENU) (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    7SK snRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    rRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    snoRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of myeloid dendritic cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    response to exogenous dsRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    nucleolar RNA helicase 2
    Names
    DEAD box protein 21
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21 (RNA helicase II/Gu)
    RH II/Gu
    RH-II/Gualpha
    gu-alpha
    nucleolar RNA helicase Gu
    nucleolar RNA helicase II
    NP_062426.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019553.2NP_062426.2  nucleolar RNA helicase 2

      See identical proteins and their annotated locations for NP_062426.2

      Status: VALIDATED

      Source sequence(s)
      BC059237, BC060220, CF182162
      Consensus CDS
      CCDS23891.1
      UniProtKB/Swiss-Prot
      Q9JIK5
      UniProtKB/TrEMBL
      Q6PCP0
      Related
      ENSMUSP00000042691.7, ENSMUST00000045866.8
      Conserved Domains (5) summary
      PRK01297
      Location:191633
      PRK01297; ATP-dependent RNA helicase RhlB; Provisional
      cd00079
      Location:501610
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:260467
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      cd12936
      Location:689781
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
      cl17173
      Location:794840
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      62580247..62602316 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001779560.1 RNA Sequence

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