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    Abcb10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 [ Mus musculus (house mouse) ]

    Gene ID: 56199, updated on 25-Nov-2021

    Summary

    Official Symbol
    Abcb10provided by MGI
    Official Full Name
    ATP-binding cassette, sub-family B (MDR/TAP), member 10provided by MGI
    Primary source
    MGI:MGI:1860508
    See related
    Ensembl:ENSMUSG00000031974
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Abc-me; Abcb12
    Summary
    This gene encodes a member of the ATP-binding cassette superfamily of transporters. ATP-binding cassette proteins transport various molecules across extra- and intra-cellular membranes. The encoded protein is localized to the mitochondrial inner membrane where it interacts with and stabilizes mitoferrin-1, and is important for heme biosynthesis. Additional evidence suggests the encoded protein is involved in oxidative stress protection and erythropoisesis. [provided by RefSeq, May 2013]
    Expression
    Broad expression in liver E14.5 (RPKM 58.9), liver E14 (RPKM 57.6) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Abcb10 in Genome Data Viewer
    Location:
    8; 8 E2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (124679198..124709877, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123952459..123983122, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (126476359..126507022, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29773 Neighboring gene actin alpha 1, skeletal muscle Neighboring gene nucleoporin 133 Neighboring gene predicted gene, 53469 Neighboring gene TATA-box binding protein associated factor 5 like Neighboring gene ribosomal protein L7A pseudogene Neighboring gene microRNA 1967 Neighboring gene URB2 ribosome biogenesis 2 homolog (S. cerevisiae)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase-coupled transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATP-binding cassette sub-family B member 10, mitochondrial
    Names
    ABC-mitochondrial erythroid protein
    ATP-binding cassette transporter 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019552.2NP_062425.1  ATP-binding cassette sub-family B member 10, mitochondrial precursor

      See identical proteins and their annotated locations for NP_062425.1

      Status: REVIEWED

      Source sequence(s)
      BC054793
      Consensus CDS
      CCDS22766.1
      UniProtKB/Swiss-Prot
      Q9JI39
      Related
      ENSMUSP00000075011.7, ENSMUST00000075578.7
      Conserved Domains (3) summary
      cd03249
      Location:458698
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      TIGR00958
      Location:8694
      3a01208; Conjugate Transporter-2 (CT2) Family protein
      pfam00664
      Location:142403
      ABC_membrane; ABC transporter transmembrane region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      124679198..124709877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154190.1XP_036010083.1  ATP-binding cassette sub-family B member 10, mitochondrial isoform X1

      Conserved Domains (3) summary
      cd03249
      Location:123363
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      cd07346
      Location:348
      ABC_6TM_exporters; TM helix 5 [structural motif]
      cl38913
      Location:395
      ABC_6TM_exporters; Six-transmembrane helical domain of the ATP-binding cassette transporters
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