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    Tdp2 tyrosyl-DNA phosphodiesterase 2 [ Mus musculus (house mouse) ]

    Gene ID: 56196, updated on 23-Jun-2021

    Summary

    Official Symbol
    Tdp2provided by MGI
    Official Full Name
    tyrosyl-DNA phosphodiesterase 2provided by MGI
    Primary source
    MGI:MGI:1860486
    See related
    Ensembl:ENSMUSG00000035958
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tt; Ttrap; D13Ertd656; D13Ertd656e
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 20.4), limb E14.5 (RPKM 14.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Tdp2 in Genome Data Viewer
    Location:
    13 A3.1; 13 10.7 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (25015642..25026136)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (24831659..24842153)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (24923528..24934022)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC005537 Neighboring gene predicted gene, 22358 Neighboring gene acyl-CoA thioesterase 13 Neighboring gene RIKEN cDNA D130043K22 gene Neighboring gene RIKEN cDNA 4932702P03 gene Neighboring gene aldhehyde dehydrogenase family 5, subfamily A1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-tyrosyl-DNA phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 5'-tyrosyl-DNA phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables endonuclease activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoric diester hydrolase activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tyrosyl-RNA phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in aggresome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tyrosyl-DNA phosphodiesterase 2
    Names
    5'-Tyr-DNA phosphodiesterase
    5'-tyrosyl-DNA phosphodiesterase
    TRAF and TNF receptor-associated protein
    tyr-DNA phosphodiesterase 2
    NP_062424.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019551.2NP_062424.1  tyrosyl-DNA phosphodiesterase 2

      See identical proteins and their annotated locations for NP_062424.1

      Status: VALIDATED

      Source sequence(s)
      AL589699, BC132511, BY719852
      Consensus CDS
      CCDS26381.1
      UniProtKB/Swiss-Prot
      Q9JJX7
      Related
      ENSMUSP00000035660.3, ENSMUST00000038039.3
      Conserved Domains (2) summary
      cd09080
      Location:124366
      TDP2; Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains
      cl21463
      Location:3874
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      25015642..25026136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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