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    Ptbp2 polypyrimidine tract binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 56195, updated on 29-Jun-2021

    Summary

    Official Symbol
    Ptbp2provided by MGI
    Official Full Name
    polypyrimidine tract binding protein 2provided by MGI
    Primary source
    MGI:MGI:1860489
    See related
    Ensembl:ENSMUSG00000028134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    brP; Ptb2; nPTB; brPTB
    Expression
    Biased expression in CNS E14 (RPKM 48.5), whole brain E14.5 (RPKM 48.4) and 12 other tissues See more
    Orthologs
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    Genomic context

    See Ptbp2 in Genome Data Viewer
    Location:
    3; 3 G1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (119512390..119578296, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (119718741..119784647, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (119421660..119486306, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23432 Neighboring gene ribosomal protein S20 pseudogene Neighboring gene ribonucleotide reductase M2 pseudogene Neighboring gene predicted gene, 23733

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    polypyrimidine tract-binding protein 2
    Names
    RRM-type RNA-binding protein brPTB
    brain-enriched PTB
    brain-enriched polypyrimidine tract-binding protein
    neural polypyrimidine tract-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310711.1NP_001297640.1  polypyrimidine tract-binding protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001297640.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC111029, AK013734, AK033964, AK135738
      Consensus CDS
      CCDS80010.1
      UniProtKB/Swiss-Prot
      Q91Z31
      Related
      ENSMUSP00000143510.2, ENSMUST00000200097.5
      Conserved Domains (1) summary
      TIGR01649
      Location:57531
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    2. NM_019550.2NP_062423.1  polypyrimidine tract-binding protein 2 isoform 1

      See identical proteins and their annotated locations for NP_062423.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC111029, AK137348
      Consensus CDS
      CCDS38616.1
      UniProtKB/Swiss-Prot
      Q91Z31
      Related
      ENSMUSP00000029780.8, ENSMUST00000029780.12
      Conserved Domains (1) summary
      TIGR01649
      Location:57532
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      119512390..119578296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501731.2XP_006501794.1  polypyrimidine tract-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006501794.1

      Conserved Domains (1) summary
      TIGR01649
      Location:57537
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    2. XM_006501732.3XP_006501795.1  polypyrimidine tract-binding protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006501795.1

      Conserved Domains (1) summary
      TIGR01649
      Location:57536
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    RNA

    1. XR_001783719.3 RNA Sequence

    2. XR_375550.4 RNA Sequence

    3. XR_375549.3 RNA Sequence

    4. XR_001783718.3 RNA Sequence

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