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    TDRD1 tudor domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 56165, updated on 5-Mar-2024

    Summary

    Official Symbol
    TDRD1provided by HGNC
    Official Full Name
    tudor domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:11712
    See related
    Ensembl:ENSG00000095627 MIM:605796; AllianceGenome:HGNC:11712
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT41.1
    Summary
    This gene encodes a protein containing a tudor domain that is thought to function in the suppression of transposable elements during spermatogenesis. The related protein in mouse forms a complex with piRNAs and Piwi proteins to promote methylation and silencing of target sequences. This gene was observed to be upregulated by ETS transcription factor ERG in prostate tumors. [provided by RefSeq, Sep 2018]
    Expression
    Biased expression in testis (RPKM 8.5) and prostate (RPKM 0.6) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TDRD1 in Genome Data Viewer
    Location:
    10q25.3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (114174874..114232666)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (115068498..115126291)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (115939046..115992425)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene UBE2V1 pseudogene 5 Neighboring gene coiled-coil domain containing 186 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:115933644-115934172 Neighboring gene microRNA 2110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:115998924-115999632 Neighboring gene MPRA-validated peak1096 silencer Neighboring gene aurora kinase A pseudogene 2 Neighboring gene von Willebrand factor A domain containing 2 Neighboring gene MPRA-validated peak1097 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116036689-116037189 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116037297-116037798 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:116045355-116045966 Neighboring gene actin filament associated protein 1 like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2843 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:116079781-116080980 Neighboring gene uncharacterized LOC105378494

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ21082

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in P granule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in germ cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in piRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in piRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in siRNA-mediated retrotransposon silencing by heterochromatin formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in P granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromatoid body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in pi-body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tudor domain-containing protein 1
    Names
    cancer/testis antigen 41.1
    testicular tissue protein Li 193

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365891.2NP_001352820.1  tudor domain-containing protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022023, BX648664
      Conserved Domains (2) summary
      pfam00567
      Location:712832
      TUDOR; Tudor domain
      pfam01753
      Location:170206
      zf-MYND; MYND finger
    2. NM_001385363.1NP_001372292.1  tudor domain-containing protein 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Consensus CDS
      CCDS7588.1
      UniProtKB/TrEMBL
      A0A140VJW6
      Conserved Domains (5) summary
      pfam00567
      Location:715832
      TUDOR; Tudor domain
      pfam01753
      Location:170206
      zf-MYND; MYND finger
      cd20408
      Location:268396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:9441059
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
    3. NM_001385364.2NP_001372293.1  tudor domain-containing protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Consensus CDS
      CCDS91352.1
      UniProtKB/Swiss-Prot
      A6NEN3, A6NMN2, B3KVI4, B4E2L5, D3DRC2, Q4G0Y8, Q6P518, Q9BXT4, Q9H7B3
      Conserved Domains (5) summary
      pfam00567
      Location:715832
      TUDOR; Tudor domain
      pfam01753
      Location:170206
      zf-MYND; MYND finger
      cd20408
      Location:268396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:9441059
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
    4. NM_001385365.1NP_001372294.1  tudor domain-containing protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Conserved Domains (5) summary
      pfam00567
      Location:715832
      TUDOR; Tudor domain
      pfam01753
      Location:170206
      zf-MYND; MYND finger
      cd20408
      Location:268396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:9441059
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
    5. NM_001385366.1NP_001372295.1  tudor domain-containing protein 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Conserved Domains (5) summary
      pfam00567
      Location:658775
      TUDOR; Tudor domain
      pfam01753
      Location:170206
      zf-MYND; MYND finger
      cd20408
      Location:268396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:8871002
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cl02573
      Location:517553
      Tudor_SF; Tudor domain superfamily
    6. NM_001385367.1NP_001372296.1  tudor domain-containing protein 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Consensus CDS
      CCDS91353.1
      UniProtKB/TrEMBL
      H9KV63
      Related
      ENSP00000358288.1, ENST00000369282.5
      Conserved Domains (5) summary
      pfam00567
      Location:715832
      TUDOR; Tudor domain
      pfam01753
      Location:170206
      zf-MYND; MYND finger
      cd20408
      Location:268396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:9441058
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
    7. NM_001385368.1NP_001372297.1  tudor domain-containing protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Consensus CDS
      CCDS91354.1
      UniProtKB/TrEMBL
      H9KV62
      Related
      ENSP00000358286.1, ENST00000369280.1
      Conserved Domains (5) summary
      pfam00567
      Location:715832
      TUDOR; Tudor domain
      pfam01753
      Location:170206
      zf-MYND; MYND finger
      cd20408
      Location:268396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:9441058
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
    8. NM_001385369.1NP_001372298.1  tudor domain-containing protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Consensus CDS
      CCDS91354.1
      UniProtKB/TrEMBL
      H9KV62
      Conserved Domains (5) summary
      pfam00567
      Location:715832
      TUDOR; Tudor domain
      pfam01753
      Location:170206
      zf-MYND; MYND finger
      cd20408
      Location:268396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:9441058
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
    9. NM_001385370.1NP_001372299.1  tudor domain-containing protein 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Conserved Domains (5) summary
      pfam00567
      Location:658726
      TUDOR; Tudor domain
      pfam01753
      Location:170206
      zf-MYND; MYND finger
      cd20408
      Location:268396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:830945
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cl02573
      Location:517553
      Tudor_SF; Tudor domain superfamily
    10. NM_001385371.1NP_001372300.1  tudor domain-containing protein 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Conserved Domains (5) summary
      pfam00567
      Location:667784
      TUDOR; Tudor domain
      pfam01753
      Location:170206
      zf-MYND; MYND finger
      cd20409
      Location:469550
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:8961010
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cl02573
      Location:268348
      Tudor_SF; Tudor domain superfamily
    11. NM_001385372.1NP_001372301.1  tudor domain-containing protein 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Conserved Domains (5) summary
      pfam00567
      Location:715832
      TUDOR; Tudor domain
      pfam01753
      Location:170206
      zf-MYND; MYND finger
      cd20408
      Location:268396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:9441058
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
    12. NM_001395205.1NP_001382134.1  tudor domain-containing protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC022023
      Consensus CDS
      CCDS91352.1
      UniProtKB/Swiss-Prot
      A6NEN3, A6NMN2, B3KVI4, B4E2L5, D3DRC2, Q4G0Y8, Q6P518, Q9BXT4, Q9H7B3
      Related
      ENSP00000511878.1, ENST00000695399.1
      Conserved Domains (5) summary
      pfam00567
      Location:715832
      TUDOR; Tudor domain
      pfam01753
      Location:170206
      zf-MYND; MYND finger
      cd20408
      Location:268396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:9441059
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
    13. NM_198795.2NP_942090.1  tudor domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_942090.1

      Status: REVIEWED

      Source sequence(s)
      AC022023, AK122916, BC035010, BQ882979, BX648664, CB136029
      Consensus CDS
      CCDS7588.1
      UniProtKB/TrEMBL
      A0A140VJW6
      Related
      ENSP00000251864.2, ENST00000251864.7
      Conserved Domains (5) summary
      pfam00567
      Location:715832
      TUDOR; Tudor domain
      pfam01753
      Location:170206
      zf-MYND; MYND finger
      cd20408
      Location:268396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:9441059
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      114174874..114232666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539962.2XP_011538264.1  tudor domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011538264.1

      UniProtKB/TrEMBL
      A0A140VJW6
      Conserved Domains (5) summary
      pfam00567
      Location:715832
      TUDOR; Tudor domain
      pfam01753
      Location:170206
      zf-MYND; MYND finger
      cd20408
      Location:268396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:9441059
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
    2. XM_011539964.3XP_011538266.1  tudor domain-containing protein 1 isoform X3

      Conserved Domains (3) summary
      cd04508
      Location:709756
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:655775
      TUDOR; Tudor domain
      pfam01753
      Location:170206
      zf-MYND; MYND finger
    3. XM_047425489.1XP_047281445.1  tudor domain-containing protein 1 isoform X6

    4. XM_017016414.3XP_016871903.1  tudor domain-containing protein 1 isoform X2

    5. XM_047425488.1XP_047281444.1  tudor domain-containing protein 1 isoform X5

    6. XM_047425487.1XP_047281443.1  tudor domain-containing protein 1 isoform X4

    7. XM_047425491.1XP_047281447.1  tudor domain-containing protein 1 isoform X7

    8. XM_047425486.1XP_047281442.1  tudor domain-containing protein 1 isoform X3

    9. XM_047425490.1XP_047281446.1  tudor domain-containing protein 1 isoform X6

    10. XM_047425492.1XP_047281448.1  tudor domain-containing protein 1 isoform X7

    11. XM_011539959.3XP_011538261.1  tudor domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011538261.1

      UniProtKB/TrEMBL
      A0A140VJW6
      Conserved Domains (5) summary
      pfam00567
      Location:715832
      TUDOR; Tudor domain
      pfam01753
      Location:170206
      zf-MYND; MYND finger
      cd20408
      Location:268396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:9441059
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
    12. XM_011539960.3XP_011538262.1  tudor domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011538262.1

      UniProtKB/TrEMBL
      A0A140VJW6
      Conserved Domains (5) summary
      pfam00567
      Location:715832
      TUDOR; Tudor domain
      pfam01753
      Location:170206
      zf-MYND; MYND finger
      cd20408
      Location:268396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:9441059
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
    13. XM_011539961.3XP_011538263.1  tudor domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011538263.1

      UniProtKB/TrEMBL
      A0A140VJW6
      Conserved Domains (5) summary
      pfam00567
      Location:715832
      TUDOR; Tudor domain
      pfam01753
      Location:170206
      zf-MYND; MYND finger
      cd20408
      Location:268396
      Tudor_TDRD1_rpt1; first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20409
      Location:517598
      Tudor_TDRD1_rpt2; second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins
      cd20411
      Location:9441059
      Tudor_TDRD1_rpt4; fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      115068498..115126291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366308.1XP_054222283.1  tudor domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A140VJW6
    2. XM_054366310.1XP_054222285.1  tudor domain-containing protein 1 isoform X3

    3. XM_054366314.1XP_054222289.1  tudor domain-containing protein 1 isoform X6

    4. XM_054366309.1XP_054222284.1  tudor domain-containing protein 1 isoform X2

    5. XM_054366313.1XP_054222288.1  tudor domain-containing protein 1 isoform X5

    6. XM_054366312.1XP_054222287.1  tudor domain-containing protein 1 isoform X4

    7. XM_054366316.1XP_054222291.1  tudor domain-containing protein 1 isoform X7

    8. XM_054366311.1XP_054222286.1  tudor domain-containing protein 1 isoform X3

    9. XM_054366315.1XP_054222290.1  tudor domain-containing protein 1 isoform X6

    10. XM_054366317.1XP_054222292.1  tudor domain-containing protein 1 isoform X7

    11. XM_054366305.1XP_054222280.1  tudor domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A140VJW6
    12. XM_054366306.1XP_054222281.1  tudor domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A140VJW6
    13. XM_054366307.1XP_054222282.1  tudor domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A140VJW6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_031278.1: Suppressed sequence

      Description
      NM_031278.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.