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    Set SET nuclear oncogene [ Mus musculus (house mouse) ]

    Gene ID: 56086, updated on 6-Sep-2021

    Summary

    Official Symbol
    Setprovided by MGI
    Official Full Name
    SET nuclear oncogeneprovided by MGI
    Primary source
    MGI:MGI:1860267
    See related
    Ensembl:ENSMUSG00000054766
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TAF-I; StF-IT; I-2PP2A; AA407739; StF-IT-1; 2610030F17Rik; 5730420M11Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 163.2), CNS E14 (RPKM 62.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Set in Genome Data Viewer
    Location:
    2; 2 B
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29952008..29962589)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30061996..30072577)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (29917563..29927315)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene spectrin alpha, non-erythrocytic 1 Neighboring gene microRNA 6997 Neighboring gene dynein 2 intermediate chain 2 Neighboring gene protein kinase N3 Neighboring gene zinc finger, DHHC domain containing 12 Neighboring gene zyg-11 related, cell cycle regulator

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC118419

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein SET
    Names
    SET translocation
    phosphatase 2A inhibitor I2PP2A
    template-activating factor I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204875.1NP_001191804.1  protein SET isoform 2

      See identical proteins and their annotated locations for NP_001191804.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the shorter isoform (2; also known as isoform beta).
      Source sequence(s)
      AK019960, BQ899734, BU756940
      Consensus CDS
      CCDS57162.1
      UniProtKB/Swiss-Prot
      Q9EQU5
      Related
      ENSMUSP00000070002.7, ENSMUST00000067996.7
      Conserved Domains (1) summary
      pfam00956
      Location:32221
      NAP; Nucleosome assembly protein (NAP)
    2. NM_023871.4NP_076360.1  protein SET isoform 1

      See identical proteins and their annotated locations for NP_076360.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1; also known as isoform alpha).
      Source sequence(s)
      AK019960, BC103791, BE331951, BU756940
      Consensus CDS
      CCDS15866.1
      UniProtKB/Swiss-Prot
      Q9EQU5
      UniProtKB/TrEMBL
      Q3T9S3
      Related
      ENSMUSP00000099930.4, ENSMUST00000102866.10
      Conserved Domains (1) summary
      pfam00956
      Location:49233
      NAP; Nucleosome assembly protein (NAP)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      29952008..29962589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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