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    Ubqln1 ubiquilin 1 [ Mus musculus (house mouse) ]

    Gene ID: 56085, updated on 5-Aug-2018

    Summary

    Official Symbol
    Ubqln1provided by MGI
    Official Full Name
    ubiquilin 1provided by MGI
    Primary source
    MGI:MGI:1860276
    See related
    Ensembl:ENSMUSG00000005312
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Da41; Dsk2; Plic1; Xdrp1; C77538; Plic-1; AU019746; D13Ertd372e; 1110046H03Rik; 1810030E05Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 72.0), adrenal adult (RPKM 65.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ubqln1 in Genome Data Viewer
    Location:
    13 B1; 13 30.95 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (58176156..58215653, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (58277517..58317014, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700066J03 gene Neighboring gene idnK gluconokinase homolog (E. coli) Neighboring gene G kinase anchoring protein 1 Neighboring gene predicted gene, 26555 Neighboring gene kinesin family member 27

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    intermediate filament binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    aggrephagy ISO
    Inferred from Sequence Orthology
    more info
     
    autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    autophagosome maturation ISO
    Inferred from Sequence Orthology
    more info
     
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of store-operated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of toll-like receptor 3 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ER-associated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    aggresome ISO
    Inferred from Sequence Orthology
    more info
     
    autophagosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    autophagosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome complex IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquilin-1
    Names
    protein linking IAP with cytoskeleton 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026842.4NP_081118.4  ubiquilin-1 isoform 1

      See identical proteins and their annotated locations for NP_081118.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC163038, AI425982, AK049298, AK165456
      Consensus CDS
      CCDS49281.1
      UniProtKB/Swiss-Prot
      Q8R317
      UniProtKB/TrEMBL
      Q3TN93
      Related
      ENSMUSP00000050191.5, ENSMUST00000058735.11
      Conserved Domains (4) summary
      smart00727
      Location:384416
      STI1; Heat shock chaperonin-binding motif
      cd01808
      Location:2898
      hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
      smart00213
      Location:2898
      UBQ; Ubiquitin homologues
      cd14399
      Location:539578
      UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
    2. NM_152234.2NP_689420.1  ubiquilin-1 isoform 2

      See identical proteins and their annotated locations for NP_689420.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC163038, AI425982, AK048534, AK165456
      Consensus CDS
      CCDS26569.1
      UniProtKB/Swiss-Prot
      Q8R317
      UniProtKB/TrEMBL
      Q3TN93
      Related
      ENSMUSP00000075782.6, ENSMUST00000076454.7
      Conserved Domains (5) summary
      smart00727
      Location:173210
      STI1; Heat shock chaperonin-binding motif
      cd01808
      Location:2898
      hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
      smart00213
      Location:2898
      UBQ; Ubiquitin homologues
      cd14399
      Location:511550
      UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
      TIGR00601
      Location:300523
      rad23; UV excision repair protein Rad23

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      58176156..58215653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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