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    Rala v-ral simian leukemia viral oncogene A (ras related) [ Mus musculus (house mouse) ]

    Gene ID: 56044, updated on 23-Sep-2018

    Summary

    Official Symbol
    Ralaprovided by MGI
    Official Full Name
    v-ral simian leukemia viral oncogene A (ras related)provided by MGI
    Primary source
    MGI:MGI:1927243
    See related
    Ensembl:ENSMUSG00000008859 Vega:OTTMUSG00000017001
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ral; Rasl1; AW322615; 3010001O15Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 28.4), CNS E14 (RPKM 21.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rala in Genome Data Viewer
    Location:
    13 A2; 13 6.05 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (17880575..17944217, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (17972409..18036051, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase 13 Neighboring gene microRNA 466i Neighboring gene predicted gene, 18859 Neighboring gene ADP-ribosylation factor 3 pseudogene Neighboring gene G patch domain and ankyrin repeats 1 pseudogene Neighboring gene Yae1 domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
      Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
    • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
      Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
    • Translocation of GLUT4 to the plasma membrane, organism-specific biosystem (from REACTOME)
      Translocation of GLUT4 to the plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Edg-2 lysophosphatidic acid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    myosin binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft localization ISO
    Inferred from Sequence Orthology
    more info
     
    neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ras-related protein Ral-A
    Names
    RAS-like, family 1
    ral-A protein
    v-ral simian leukemia viral oncogene homolog A (ras related)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019491.5NP_062364.3  ras-related protein Ral-A precursor

      See identical proteins and their annotated locations for NP_062364.3

      Status: PROVISIONAL

      Source sequence(s)
      CT009754
      Consensus CDS
      CCDS26255.1
      UniProtKB/Swiss-Prot
      P63321
      Related
      ENSMUSP00000009003.7, OTTMUSP00000018472, ENSMUST00000009003.8, OTTMUST00000041223
      Conserved Domains (1) summary
      cd04139
      Location:15177
      RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      17880575..17944217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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