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    Ccnl2 cyclin L2 [ Mus musculus (house mouse) ]

    Gene ID: 56036, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ccnl2provided by MGI
    Official Full Name
    cyclin L2provided by MGI
    Primary source
    MGI:MGI:1927119
    See related
    Ensembl:ENSMUSG00000029068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pce; ani; Pcee; SB138; Ania-6b; AA409936; AW261738; HCLA-150; 1700010A01Rik; 1810019L15Rik; 2010319M22Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 65.5), bladder adult (RPKM 45.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ccnl2 in Genome Data Viewer
    Location:
    4 E2; 4 87.47 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155894468..155909000)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155810219..155824543)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (155186598..155198652)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 65 Neighboring gene mitochondrial ribosomal protein L20 Neighboring gene aurora kinase A interacting protein 1 Neighboring gene matrix-remodelling associated 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC21593

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclin-L2
    Names
    cyclin Ania-6b
    paneth cell enhanced expression
    paneth cell-enhanced expression protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207678.1NP_997561.1  cyclin-L2

      See identical proteins and their annotated locations for NP_997561.1

      Status: VALIDATED

      Source sequence(s)
      AB041605, AK048244, CD348864
      Consensus CDS
      CCDS19042.1
      UniProtKB/Swiss-Prot
      Q9JJA7
      Related
      ENSMUSP00000030944.5, ENSMUST00000030944.11
      Conserved Domains (2) summary
      smart00385
      Location:198280
      CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma
      cd00043
      Location:75151
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      155894468..155909000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164254.1XP_036020147.1  cyclin-L2 isoform X1

      Conserved Domains (2) summary
      cd20590
      Location:33188
      CYCLIN_CCNL2_rpt1; first cyclin box found in cyclin-2 (CCNL2) and similar proteins
      cd20593
      Location:193315
      CYCLIN_CCNL2_rpt2; second cyclin box found in cyclin-2 (CCNL2) and similar proteins
    2. XM_011250305.4XP_011248607.2  cyclin-L2 isoform X2

      Conserved Domains (1) summary
      cl40454
      Location:195
      CYCLIN_SF; Cyclin box fold superfamily
    3. XM_036164256.1XP_036020149.1  cyclin-L2 isoform X3

      Conserved Domains (1) summary
      cl40454
      Location:195
      CYCLIN_SF; Cyclin box fold superfamily
    4. XM_036164255.1XP_036020148.1  cyclin-L2 isoform X2

      Conserved Domains (1) summary
      cl40454
      Location:195
      CYCLIN_SF; Cyclin box fold superfamily
    5. XM_030253679.2XP_030109539.1  cyclin-L2 isoform X3

      Conserved Domains (1) summary
      cl40454
      Location:195
      CYCLIN_SF; Cyclin box fold superfamily

    RNA

    1. XR_881434.4 RNA Sequence

    2. XR_001784166.3 RNA Sequence

    3. XR_001784165.3 RNA Sequence

    4. XR_003954988.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_018856.2: Suppressed sequence

      Description
      NM_018856.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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