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    Agpat1 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) [ Mus musculus (house mouse) ]

    Gene ID: 55979, updated on 31-Jan-2019

    Summary

    Official Symbol
    Agpat1provided by MGI
    Official Full Name
    1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)provided by MGI
    Primary source
    MGI:MGI:1932075
    See related
    Ensembl:ENSMUSG00000034254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1-AGP; 1-AGPAT; AW047140
    Expression
    Ubiquitous expression in duodenum adult (RPKM 284.0), testis adult (RPKM 273.5) and 27 other tissues See more
    Orthologs

    Genomic context

    See Agpat1 in Genome Data Viewer
    Location:
    17 B1; 17 18.18 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (34604303..34613449)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34742806..34750394)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene advanced glycosylation end product-specific receptor Neighboring gene ring finger protein 5 Neighboring gene EGF-like domain 8 Neighboring gene palmitoyl-protein thioesterase 2 Neighboring gene proline-rich transmembrane protein 1 Neighboring gene FK506 binding protein-like Neighboring gene activating transcription factor 6 beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    1-acylglycerol-3-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    1-acylglycerol-3-phosphate O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    1-acylglycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring acyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidic acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
    Names
    1-AGP acyltransferase 1
    1-AGPAT 1
    Lpaat-alpha
    lysophosphatidic acid acyltransferase alpha
    NP_001156851.1
    NP_061350.3
    XP_006524710.1
    XP_006524711.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163379.1NP_001156851.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha precursor

      See identical proteins and their annotated locations for NP_001156851.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      CT009767
      Consensus CDS
      CCDS37590.1
      UniProtKB/Swiss-Prot
      O35083
      UniProtKB/TrEMBL
      A0A0R4J263
      Related
      ENSMUSP00000048573.8, ENSMUST00000037489.14
      Conserved Domains (2) summary
      cd07989
      Location:66253
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
      COG0204
      Location:41266
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
    2. NM_018862.3NP_061350.3  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha precursor

      See identical proteins and their annotated locations for NP_061350.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      CT009767
      Consensus CDS
      CCDS37590.1
      UniProtKB/Swiss-Prot
      O35083
      UniProtKB/TrEMBL
      A0A0R4J263
      Related
      ENSMUSP00000109776.3, ENSMUST00000114140.9
      Conserved Domains (2) summary
      cd07989
      Location:66253
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
      COG0204
      Location:41266
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      34604303..34613449
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524647.2XP_006524710.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X1

      See identical proteins and their annotated locations for XP_006524710.1

      UniProtKB/Swiss-Prot
      O35083
      UniProtKB/TrEMBL
      A0A0R4J263
      Conserved Domains (2) summary
      cd07989
      Location:66253
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
      COG0204
      Location:41266
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
    2. XM_006524648.1XP_006524711.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X1

      See identical proteins and their annotated locations for XP_006524711.1

      UniProtKB/Swiss-Prot
      O35083
      UniProtKB/TrEMBL
      A0A0R4J263
      Conserved Domains (2) summary
      cd07989
      Location:66253
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
      COG0204
      Location:41266
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

    Reference GRCm38.p4 129X1/SvJ

    Genomic

    1. NT_039662.3 Reference GRCm38.p4 129X1/SvJ

      Range
      854630..862218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187027.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      925427..933015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/ShiLtJ

    Genomic

    1. NT_187004.1 Reference GRCm38.p4 NOD/ShiLtJ

      Range
      925677..933265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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