Ift20 intraflagellar transport 20 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ift20provided by MGI
Official Full Name: intraflagellar transport 20provided by MGI
Primary source: MGI:MGI:1915585
See related: Ensembl:ENSMUSG00000001105 Vega:OTTMUSG00000000139
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mIFT20; AU015496; 0610009H04Rik
Expression: Ubiquitous expression in duodenum adult (RPKM 42.4), small intestine adult (RPKM 37.8) and 28 other tissues See more
Orthologs: human all

Genomic context

Location:: 11; 11 B5

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCm38.p4 (GCF_000001635.24)	11	NC_000077.6 (78536436..78541473)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	11	NC_000077.5 (78349938..78354975)

Chromosome 11 - NC_000077.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

intraflagellar transport protein 20 (IFT20) interacts with E3 ubiquitin ligases c-Cbl and Cbl-b and is required for Cbl-mediated ubiquitination and internalization of PDGFRalpha for feedback inhibition of receptor signaling.
Title: IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases.
IFT20 is required for the delivery of the intracellular pool of LAT to the immune synapse in naive primary T lymphocytes.
Title: IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo.
Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea.
Title: Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea.
This work is a strong support of a model of opsin transport where IFT20 is involved in the movement from the Golgi complex to the base of the cilium
Title: Distinct functions for IFT140 and IFT20 in opsin transport.
Mxi1 regulates Ift20 promoter activity via Ets-1 binding to the Ift20 promoter. These results indicate that inactivating Mxi1 induces ciliary defects in polycystic kidney.
Title: Inactivation of max-interacting protein 1 induces renal cilia disassembly through reduction in levels of intraflagellar transport 20 in polycystic kidney.
Data show that loss of IFT20 during cone development leads to opsin accumulation in the inner segment even when the connecting cilium and outer segment are still intact.
Title: IFT20 is required for opsin trafficking and photoreceptor outer segment development.
An interaction between SPEF2 and the intraflagellar transport protein IFT20 in the testis.
Title: Expression of SPEF2 during mouse spermatogenesis and identification of IFT20 as an interacting protein.
IFT20 is the only complex B protein that localizes to the Golgi apparatus.
Title: Characterization of mouse IFT complex B.
GMAP210 and IFT20 function together at the Golgi in the sorting of proteins destined for the ciliary membrane.
Title: The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex.
IFT20 functions to couple extracellular events to cell proliferation and differentiation and deletion results in cystic kidney diseease.
Title: Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Pathways from BioSystems

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Cilium Assembly, organism-specific biosystem (from REACTOME)
Cilium Assembly, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Intraflagellar transport, organism-specific biosystem (from REACTOME)
Intraflagellar transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
Organelle biogenesis and maintenance, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Ift20 gene: The Ift20 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 241 organisms have orthologs with human gene Ift20
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
Rab GTPase binding	ISO Inferred from Sequence Orthology more info
opsin binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cardiac muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
cell projection organization	IEA Inferred from Electronic Annotation more info
centrosome localization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
centrosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
cilium assembly	ISO Inferred from Sequence Orthology more info
cochlea development	IMP Inferred from Mutant Phenotype more info	PubMed
establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
inner ear receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
intraciliary transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
intraciliary transport	IC Inferred by Curator more info	PubMed
intraciliary transport	IMP Inferred from Mutant Phenotype more info	PubMed
kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
opsin transport	IMP Inferred from Mutant Phenotype more info	PubMed
photoreceptor cell outer segment organization	IMP Inferred from Mutant Phenotype more info	PubMed
protein localization to Golgi apparatus	ISO Inferred from Sequence Orthology more info
protein localization to cilium	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein localization to cilium	IMP Inferred from Mutant Phenotype more info	PubMed
protein localization to cilium	ISO Inferred from Sequence Orthology more info
protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of platelet-derived growth factor receptor-alpha signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
cell projection	IEA Inferred from Electronic Annotation more info
centriole	IDA Inferred from Direct Assay more info	PubMed
centrosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
centrosome	IDA Inferred from Direct Assay more info	PubMed
centrosome	ISO Inferred from Sequence Orthology more info
ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
ciliary base	IDA Inferred from Direct Assay more info	PubMed
cilium	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cilium	IDA Inferred from Direct Assay more info	PubMed
cis-Golgi network	ISO Inferred from Sequence Orthology more info
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
dendrite terminus	IDA Inferred from Direct Assay more info	PubMed
intraciliary transport particle B	IBA Inferred from Biological aspect of Ancestor more info	PubMed
intraciliary transport particle B	IDA Inferred from Direct Assay more info	PubMed
kinociliary basal body	IDA Inferred from Direct Assay more info	PubMed
microvillus	IDA Inferred from Direct Assay more info	PubMed
motile cilium	IDA Inferred from Direct Assay more info	PubMed
photoreceptor connecting cilium	IDA Inferred from Direct Assay more info	PubMed
photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
stereocilium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: intraflagellar transport protein 20 homolog

Names: intraflagellar transport 20 homolog; uterine protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.