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    Mpc1 mitochondrial pyruvate carrier 1 [ Mus musculus (house mouse) ]

    Gene ID: 55951, updated on 12-Mar-2019

    Summary

    Official Symbol
    Mpc1provided by MGI
    Official Full Name
    mitochondrial pyruvate carrier 1provided by MGI
    Primary source
    MGI:MGI:1915240
    See related
    Ensembl:ENSMUSG00000023861
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Brp44l; 0610006G08Rik; 3830411I18Rik
    Expression
    Ubiquitous expression in heart adult (RPKM 57.7), subcutaneous fat pad adult (RPKM 57.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mpc1 in Genome Data Viewer
    Location:
    17 A1; 17 4.92 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (8283813..8297662)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (8476678..8490526)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene chemokine (C-C motif) receptor 6 Neighboring gene predicted gene, 33799 Neighboring gene predicted gene 8465 Neighboring gene uncharacterized LOC108167375 Neighboring gene RIKEN cDNA 4930506C21 gene Neighboring gene SFT2 domain containing 1 Neighboring gene proline rich 18

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Glycolysis and Gluconeogenesis, organism-specific biosystem (from WikiPathways)
      Glycolysis and Gluconeogenesis, organism-specific biosystemGlycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOOâ?? + H+. The free energy released in this process is used to form the ATP and NADH. Gluconeogenesis is a met...

    General gene information

    Markers

    Homology

    Clone Names

    • MGC117549

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    pyruvate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to pyruvate transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane HDA PubMed 
    mitochondrion HDA PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitochondrial pyruvate carrier 1
    Names
    apoptosis-regulating basic protein
    brain protein 44-like protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364918.1NP_001351847.1  mitochondrial pyruvate carrier 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164431, AK002266, BY160030, BY256631
      Conserved Domains (1) summary
      pfam03650
      Location:281
      MPC; Uncharacterized protein family (UPF0041)
    2. NM_001364919.1NP_001351848.1  mitochondrial pyruvate carrier 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC164431
      Conserved Domains (1) summary
      pfam03650
      Location:82163
      MPC; Uncharacterized protein family (UPF0041)
    3. NM_018819.5NP_061289.1  mitochondrial pyruvate carrier 1 isoform 1

      See identical proteins and their annotated locations for NP_061289.1

      Status: VALIDATED

      Source sequence(s)
      AC164431, AK013391, BY160030
      Consensus CDS
      CCDS49944.1
      UniProtKB/Swiss-Prot
      P63030
      UniProtKB/TrEMBL
      Q3UX28
      Related
      ENSMUSP00000119443.1, ENSMUST00000155364.7
      Conserved Domains (1) summary
      pfam03650
      Location:24105
      MPC; Uncharacterized protein family (UPF0041)

    RNA

    1. NR_157360.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC164431

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      8283813..8297662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246219.2XP_011244521.1  mitochondrial pyruvate carrier 1 isoform X1

      See identical proteins and their annotated locations for XP_011244521.1

      UniProtKB/TrEMBL
      D3Z5S0
      Related
      ENSMUSP00000116307.1, ENSMUST00000130559.1
      Conserved Domains (1) summary
      pfam03650
      Location:382
      MPC; uncharacterized protein family (UPF0041)
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